O C Martínez-Ramírez1, C Castro-Hernández2, R Pérez-Morales3, L Casas-Ávila4, Ramos-García M de Lorena5, A Salazar-Piña5, J Rubio2. 1. Facultad de Nutrición, Universidad Autónoma del Estado de Morelos, Río Iztacihuatl S/N. Col. Vista Hermosa,, C.P. 62350, Ciudad de México, Mexico. celeste.martinez@uaem.mx. 2. Departamento de Medicina Genómica Y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Apartado, Postal 70228, C.P. 04510, Ciudad de México, Mexico. 3. Facultad de Ciencias Químicas, Departamento de Biología Molecular, Universidad Juárez del Estado de Durango, C.P. j35010, Durango, Mexico. 4. Departamento de Genética, Instituto Nacional de Rehabilitación, C.P. 14389, Ciudad de México, Mexico. 5. Facultad de Nutrición, Universidad Autónoma del Estado de Morelos, Río Iztacihuatl S/N. Col. Vista Hermosa,, C.P. 62350, Ciudad de México, Mexico.
Abstract
Prolonged exposure to estrogens is the main factor associated with the risk and prognosis of breast cancer (BC). The genes involved in the biotransformation of estrogens and xenobiotics have allelic variants with modified enzymatic activities. We investigated the association of nine polymorphisms of some genes from the classical estrogen pathway with the risk of breast cancer and their role in the clinicopathological characteristics of poor clinical prognosis in a sample of Mexican women with BC. METHODS: We included 150 controls and 150 cases matched by age. To analyze the selected polymorphisms, TaqMan assays and high-resolution melting (HRM) analysis were used. RESULTS: The polymorphisms of the genes ERα, CYP1A1, CYP1B1, COMT, MGMT, and XRCC1 were positively associated with the BC risk. We found negative associations between CYP1B1G/G genotype and tumor size, and status of lymph node, estrogen receptor, triple negative, and survival. CONCLUSIONS: The polymorphisms included in this study are associated not only with the risk of BC, but also with some clinicopathological characteristics for poor prognosis of patients with breast cancer, highlighting the important role of CYP1B1 Leu432Val polymorphism.
Prolonged exposure to estrogens is the main factor associated with the risk and prognosis of breast cancer (BC). The genes involved in the biotransformation of estrogens and xenobiotics have allelic variants with modified enzymatic activities. We investigated the association of nine polymorphisms of some genes from the classical estrogen pathway with the risk of breast cancer and their role in the clinicopathological characteristics of poor clinical prognosis in a sample of Mexican women with BC. METHODS: We included 150 controls and 150 cases matched by age. To analyze the selected polymorphisms, TaqMan assays and high-resolution melting (HRM) analysis were used. RESULTS: The polymorphisms of the genes ERα, CYP1A1, CYP1B1, COMT, MGMT, and XRCC1 were positively associated with the BC risk. We found negative associations between CYP1B1G/G genotype and tumor size, and status of lymph node, estrogen receptor, triple negative, and survival. CONCLUSIONS: The polymorphisms included in this study are associated not only with the risk of BC, but also with some clinicopathological characteristics for poor prognosis of patients with breast cancer, highlighting the important role of CYP1B1 Leu432Val polymorphism.
Entities:
Keywords:
Breast cancer; Genetic polymorphism; Mexican women; Prognosis
Authors: Christina Justenhoven; Christiane B Pierl; Susanne Haas; Hans-Peter Fischer; Christian Baisch; Ute Hamann; Volker Harth; Beate Pesch; Thomas Brüning; Caren Vollmert; Thomas Illig; Jürgen Dippon; Yon-Dschun Ko; Hiltrud Brauch Journal: Breast Cancer Res Treat Date: 2007-10-06 Impact factor: 4.872
Authors: O C Martínez-Ramírez; R Pérez-Morales; C Castro; A Flores-Díaz; K E Soto-Cruz; A Astorga-Ramos; M E Gonsebatt; L Casas; M Valdés-Flores; J Rubio Journal: Breast Date: 2012-09-21 Impact factor: 4.380