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Literature DB >> 33514888

How to redesign COVID vaccines so they protect against variants.

Ewen Callaway, Heidi Ledford.

Abstract

Entities: Disease

Keywords: Immunology; Infection; SARS-CoV-2; Vaccines

Year: 2021 PMID： 33514888 DOI： 10.1038/d41586-021-00241-6

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

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28 in total

1. SARS-CoV-2 prefusion spike protein stabilized by six rather than two prolines is more potent for inducing antibodies that neutralize viral variants of concern.

Authors: Mijia Lu; Michelle Chamblee; Yuexiu Zhang; Chengjin Ye; Piyush Dravid; Jun-Gyu Park; K C Mahesh; Sheetal Trivedi; Satyapramod Murthy; Himanshu Sharma; Cole Cassady; Supranee Chaiwatpongsakorn; Xueya Liang; Jacob S Yount; Prosper N Boyaka; Mark E Peeples; Luis Martinez-Sobrido; Amit Kapoor; Jianrong Li
Journal: Proc Natl Acad Sci U S A Date: 2022-08-22 Impact factor: 12.779

2. Mutational analysis of SARS-CoV-2 variants of concern reveals key tradeoffs between receptor affinity and antibody escape.

Authors: Emily K Makowski; John S Schardt; Matthew D Smith; Peter M Tessier
Journal: PLoS Comput Biol Date: 2022-05-31 Impact factor: 4.779

How to redesign COVID vaccines so they protect against variants.

1. SARS-CoV-2 prefusion spike protein stabilized by six rather than two prolines is more potent for inducing antibodies that neutralize viral variants of concern.

2. Mutational analysis of SARS-CoV-2 variants of concern reveals key tradeoffs between receptor affinity and antibody escape.

Review 3. Fast-spreading SARS-CoV-2 variants: challenges to and new design strategies of COVID-19 vaccines.

4. Accelerated vaccine rollout is imperative to mitigate highly transmissible COVID-19 variants.

5. Targeting Future Pandemics, a Case for De Novo Purine Synthesis and Basic Research.

6. Metabolic Profiling from an Asymptomatic Ferret Model of SARS-CoV-2 Infection.

Review 7. Micronutrient therapy and effective immune response: a promising approach for management of COVID-19.

Review 8. SARS-CoV-2 Variants, Vaccines, and Host Immunity.

Review 9. Immunoglobulin Y for Potential Diagnostic and Therapeutic Applications in Infectious Diseases.

Review 10. SARS-CoV-2 Vaccines Based on the Spike Glycoprotein and Implications of New Viral Variants.