Literature DB >> 33514743

A single-dose live attenuated chimeric vaccine candidate against Zika virus.

Wei-Xin Chin1, Regina Ching Hua Lee1, Parveen Kaur1, Tian Sheng Lew1, Thinesshwary Yogarajah1, Hao Yuin Kong2, Zi-Yun Teo1, Cyrill Kafi Salim1, Rong-Rong Zhang3, Xiao-Feng Li3, Sylvie Alonso4,5, Cheng-Feng Qin3, Justin Jang Hann Chu6,7,8.   

Abstract

The mosquito-borne Zika virus is an emerging pathogen from the Flavivirus genus for which there are no approved antivirals or vaccines. Using the clinically validated PDK-53 dengue virus vaccine strain as a backbone, we created a chimeric dengue/Zika virus, VacDZ, as a live attenuated vaccine candidate against Zika virus. VacDZ demonstrates key markers of attenuation: small plaque phenotype, temperature sensitivity, attenuation of neurovirulence in suckling mice, and attenuation of pathogenicity in interferon deficient adult AG129 mice. VacDZ may be administered as a traditional live virus vaccine, or as a DNA-launched vaccine that produces live VacDZ in vivo after delivery. Both vaccine formulations induce a protective immune response against Zika virus in AG129 mice, which includes neutralising antibodies and a strong Th1 response. This study demonstrates that VacDZ is a safe and effective vaccine candidate against Zika virus.

Entities:  

Year:  2021        PMID： 33514743     DOI： 10.1038/s41541-021-00282-y

Source DB:  PubMed          Journal:  NPJ Vaccines        ISSN： 2059-0105            Impact factor:   7.344


  42 in total

1.  Dengue 2 PDK-53 virus as a chimeric carrier for tetravalent dengue vaccine development.

Authors:  Claire Y-H Huang; Siritorn Butrapet; Kiyotaka R Tsuchiya; Natth Bhamarapravati; Duane J Gubler; Richard M Kinney
Journal:  J Virol       Date:  2003-11       Impact factor: 5.103

2.  Chimeric dengue type 2 (vaccine strain PDK-53)/dengue type 1 virus as a potential candidate dengue type 1 virus vaccine.

Authors:  C Y Huang; S Butrapet; D J Pierro; G J Chang; A R Hunt; N Bhamarapravati; D J Gubler; R M Kinney
Journal:  J Virol       Date:  2000-04       Impact factor: 5.103

3.  Chimeric dengue 2 PDK-53/West Nile NY99 viruses retain the phenotypic attenuation markers of the candidate PDK-53 vaccine virus and protect mice against lethal challenge with West Nile virus.

Authors:  Claire Y-H Huang; Shawn J Silengo; Melissa C Whiteman; Richard M Kinney
Journal:  J Virol       Date:  2005-06       Impact factor: 5.103

Review 4.  Biochemistry and Molecular Biology of Flaviviruses.

Authors:  Nicholas J Barrows; Rafael K Campos; Kuo-Chieh Liao; K Reddisiva Prasanth; Ruben Soto-Acosta; Shih-Chia Yeh; Geraldine Schott-Lerner; Julien Pompon; October M Sessions; Shelton S Bradrick; Mariano A Garcia-Blanco
Journal:  Chem Rev       Date:  2018-04-13       Impact factor: 60.622

Review 5.  The emergence of Zika virus and its new clinical syndromes.

Authors:  Theodore C Pierson; Michael S Diamond
Journal:  Nature       Date:  2018-08-29       Impact factor: 49.962

Review 6.  Zika Virus.

Authors:  Didier Musso; Duane J Gubler
Journal:  Clin Microbiol Rev       Date:  2016-07       Impact factor: 26.132

Review 7.  An overview of mosquito vectors of Zika virus.

Authors:  Sébastien Boyer; Elodie Calvez; Thais Chouin-Carneiro; Diawo Diallo; Anna-Bella Failloux
Journal:  Microbes Infect       Date:  2018-03-02       Impact factor: 2.700

8.  Persistence and infectivity of Zika virus in semen after returning from endemic areas: Report of 5 cases.

Authors:  S García-Bujalance; A Gutiérrez-Arroyo; F De la Calle; M Díaz-Menéndez; Jose R Arribas; J García-Rodríguez; M Arsuaga
Journal:  J Clin Virol       Date:  2017-10-13       Impact factor: 3.168

9.  The association between Zika virus infection and microcephaly in Brazil 2015-2017: An observational analysis of over 4 million births.

Authors:  Oliver J Brady; Aaron Osgood-Zimmerman; Nicholas J Kassebaum; Sarah E Ray; Valdelaine E M de Araújo; Aglaêr A da Nóbrega; Livia C V Frutuoso; Roberto C R Lecca; Antony Stevens; Bruno Zoca de Oliveira; José M de Lima; Isaac I Bogoch; Philippe Mayaud; Thomas Jaenisch; Ali H Mokdad; Christopher J L Murray; Simon I Hay; Robert C Reiner; Fatima Marinho
Journal:  PLoS Med       Date:  2019-03-05       Impact factor: 11.069

Review 10.  Prevalence of asymptomatic Zika virus infection: a systematic review.

Authors:  Michelle M Haby; Mariona Pinart; Vanessa Elias; Ludovic Reveiz
Journal:  Bull World Health Organ       Date:  2018-04-27       Impact factor: 9.408
View more
  2 in total

1.  Single dose of chimeric dengue-2/Zika vaccine candidate protects mice and non-human primates against Zika virus.

Authors:  Whitney R Baldwin; Holli A Giebler; Janae L Stovall; Ginger Young; Kelly J Bohning; Hansi J Dean; Jill A Livengood; Claire Y-H Huang
Journal:  Nat Commun       Date:  2021-12-16       Impact factor: 14.919

2.  Recombinant vesicular stomatitis vaccine against Nipah virus has a favorable safety profile: Model for assessment of live vaccines with neurotropic potential.

Authors:  Thomas P Monath; Richard Nichols; Lynda Tussey; Kelly Scappaticci; Thaddeus G Pullano; Mary D Whiteman; Nikos Vasilakis; Shannan L Rossi; Rafael Kroon Campos; Sasha R Azar; Heidi M Spratt; Brent L Seaton; W Tad Archambault; Yanina V Costecalde; Evan H Moore; Roger J Hawks; Joan Fusco
Journal:  PLoS Pathog       Date:  2022-06-27       Impact factor: 7.464
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.