| Literature DB >> 335145 |
L Raij, W F Keane, A F Michael.
Abstract
Unilateral renal cortical necrosis was selectively induced by in situ perfusion of the rabbit kidney with a perfusate containing 50 microgram of endotoxin followed by the i.v. administration of 250 microgram of endotoxin 24 hr later. The results strongly support the idea that the initial event in the genesis of renal cortical necrosis during the Shwartzman reaction is a specific local effect of endotoxin on the vascular endothelium.Entities:
Mesh：
Substances：
Year: 1977 PMID： 335145 DOI： 10.1038/ki.1977.85
Source DB: PubMed Journal: Kidney Int ISSN： 0085-2538 Impact factor: 10.612