Literature DB >> 3351394

On the formation of circulating patterns of excitation in anisotropic excitable media.

J P Keener1.   

Abstract

We present a model of excitable media with the feature that it has a vulnerable phase during which a premature current stimulus will result in the formation of a reentrant self-sustained wave of excitation. The model exploits anisotropic coupling of identical cells, and is therefore useful as a model for the myocardium. We give rigorous verification that there is a vulnerable phase, and demonstrate numerically that permanently rotating waves are formed. Finally, it is shown that the direction of fastest propagation in myocardium is not necessarily the direction of highest safety factor, contrary to commonly accepted opinion.

Mesh:

Year:  1988        PMID: 3351394     DOI: 10.1007/bf00280171

Source DB:  PubMed          Journal:  J Math Biol        ISSN: 0303-6812            Impact factor:   2.259


  15 in total

1.  A COMPUTER MODEL OF ATRIAL FIBRILLATION.

Authors:  G K MOE; W C RHEINBOLDT; J A ABILDSKOV
Journal:  Am Heart J       Date:  1964-02       Impact factor: 4.749

2.  Directional differences of impulse spread in trabecular muscle from mammalian heart.

Authors:  L Clerc
Journal:  J Physiol       Date:  1976-02       Impact factor: 5.182

3.  Numerical solution of a nonlinear advance-delay-differential equation from nerve conduction theory.

Authors:  H Chi; J Bell; B Hassard
Journal:  J Math Biol       Date:  1986       Impact factor: 2.259

4.  Intercalated discs as a cause for discontinuous propagation in cardiac muscle: a theoretical simulation.

Authors:  P J Diaz; Y Rudy; R Plonsey
Journal:  Ann Biomed Eng       Date:  1983       Impact factor: 3.934

Review 5.  The nature of electrical propagation in cardiac muscle.

Authors:  M S Spach; J M Kootsey
Journal:  Am J Physiol       Date:  1983-01

6.  Sudden cardia death: a problem in topology.

Authors:  A T Winfree
Journal:  Sci Am       Date:  1983-05       Impact factor: 2.142

7.  Effects of the discrete pattern of electrical coupling on propagation through an electrical syncytium.

Authors:  R W Joyner
Journal:  Circ Res       Date:  1982-02       Impact factor: 17.367

8.  The discontinuous nature of propagation in normal canine cardiac muscle. Evidence for recurrent discontinuities of intracellular resistance that affect the membrane currents.

Authors:  M S Spach; W T Miller; D B Geselowitz; R C Barr; J M Kootsey; E A Johnson
Journal:  Circ Res       Date:  1981-01       Impact factor: 17.367

9.  Computer simulation of arrhythmias in a network of coupled excitable elements.

Authors:  F J van Capelle; D Durrer
Journal:  Circ Res       Date:  1980-09       Impact factor: 17.367

10.  Simple finite-element model accounts for wide range of cardiac dysrhythmias.

Authors:  J M Smith; R J Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  1984-01       Impact factor: 11.205

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  2 in total

1.  Initiation and stability of reentry in two coupled excitable fibers.

Authors:  A Palmer; J Brindley; A V Holden
Journal:  Bull Math Biol       Date:  1992-11       Impact factor: 1.758

Review 2.  Mechanisms of ventricular arrhythmias: a dynamical systems-based perspective.

Authors:  Elizabeth M Cherry; Flavio H Fenton; Robert F Gilmour
Journal:  Am J Physiol Heart Circ Physiol       Date:  2012-03-30       Impact factor: 4.733

  2 in total

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