| Literature DB >> 33513719 |
Margot Jarrige1,2,3, Elie Frank1,2,3, Elise Herardot1,2, Sabrina Martineau1,2, Annabelle Darle1,2,3, Manon Benabides1,2,3, Sophie Domingues1,2,3, Olivier Chose1,2,3, Walter Habeler1,2,3, Judith Lorant1,2, Christine Baldeschi1,2, Cécile Martinat1,2, Christelle Monville1,2, Lise Morizur1,2,3, Karim Ben M'Barek1,2,3.
Abstract
The rapid progress in the field of stem cell research has laid strong foundations for their use in regenerative medicine applications of injured or diseased tissues. Growing evidences indicate that some observed therapeutic outcomes of stem cell-based therapy are due to paracrine effects rather than long-term engraftment and survival of transplanted cells. Given their ability to cross biological barriers and mediate intercellular information transfer of bioactive molecules, extracellular vesicles are being explored as potential cell-free therapeutic agents. In this review, we first discuss the state of the art of regenerative medicine and its current limitations and challenges, with particular attention on pluripotent stem cell-derived products to repair organs like the eye, heart, skeletal muscle and skin. We then focus on emerging beneficial roles of extracellular vesicles to alleviate these pathological conditions and address hurdles and operational issues of this acellular strategy. Finally, we discuss future directions and examine how careful integration of different approaches presented in this review could help to potentiate therapeutic results in preclinical models and their good manufacturing practice (GMP) implementation for future clinical trials.Entities:
Keywords: acellular therapy; cell therapy; exosome; extracellular vesicles; pluripotent stem cells
Year: 2021 PMID： 33513719 DOI： 10.3390/cells10020240
Source DB: PubMed Journal: Cells ISSN： 2073-4409 Impact factor: 6.600