OBJECTIVES: Critical care workers were considered to be at high risk of severe acute respiratory syndrome coronavirus-2 infection from patients during the first wave of the pandemic. Staff symptoms, previous swab testing, and antibody prevalence were correlated with patient admissions to investigate this assumption. DESIGN: Cross-sectional study. SETTING: A large critical care department in a tertiary-care teaching hospital in London, United Kingdom. SUBJECTS: Staff working in critical care. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Participants completed a questionnaire and provided a serum sample for severe acute respiratory syndrome coronavirus-2 antibody testing over a 3-day period in April 2020. We compared the timing of symptoms in staff to the coronavirus disease 2019 patient admissions to critical care. We also identified factors associated with antibody detection. Of 625 staff 384 (61.4%) reported previous symptoms and 124 (19.8%) had sent a swab for testing. Severe acute respiratory syndrome coronavirus-2 infection had been confirmed in 37 of those swabbed (29.8%). Overall, 21% (131/625) had detectable severe acute respiratory syndrome coronavirus-2 antibody, of whom 9.9% (13/131) had been asymptomatic. The peak onset of symptoms among staff occurred 2 weeks before the peak in coronavirus disease 2019 patient admissions. Staff who worked in multiple departments across the hospital were more likely to be seropositive. Staff with a symptomatic household contact were also more likely to be seropositive at 31.3%, compared with 16.2% in those without (p < 0.0001). CONCLUSIONS: Staff who developed coronavirus disease 2019 were less likely to have caught it from their patients in critical care. Other staff, other areas of the hospital, and the wider community are more likely sources of infection. These findings indicate that personal protective equipment was effective at preventing transmission from patients. However, staff also need to maintain protective measures away from the bedside.
OBJECTIVES: Critical care workers were considered to be at high risk of severe acute respiratory syndrome coronavirus-2 infection from patients during the first wave of the pandemic. Staff symptoms, previous swab testing, and antibody prevalence were correlated with patient admissions to investigate this assumption. DESIGN: Cross-sectional study. SETTING: A large critical care department in a tertiary-care teaching hospital in London, United Kingdom. SUBJECTS: Staff working in critical care. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Participants completed a questionnaire and provided a serum sample for severe acute respiratory syndrome coronavirus-2 antibody testing over a 3-day period in April 2020. We compared the timing of symptoms in staff to the coronavirus disease 2019 patient admissions to critical care. We also identified factors associated with antibody detection. Of 625 staff 384 (61.4%) reported previous symptoms and 124 (19.8%) had sent a swab for testing. Severe acute respiratory syndrome coronavirus-2 infection had been confirmed in 37 of those swabbed (29.8%). Overall, 21% (131/625) had detectable severe acute respiratory syndrome coronavirus-2 antibody, of whom 9.9% (13/131) had been asymptomatic. The peak onset of symptoms among staff occurred 2 weeks before the peak in coronavirus disease 2019 patient admissions. Staff who worked in multiple departments across the hospital were more likely to be seropositive. Staff with a symptomatic household contact were also more likely to be seropositive at 31.3%, compared with 16.2% in those without (p < 0.0001). CONCLUSIONS: Staff who developed coronavirus disease 2019 were less likely to have caught it from their patients in critical care. Other staff, other areas of the hospital, and the wider community are more likely sources of infection. These findings indicate that personal protective equipment was effective at preventing transmission from patients. However, staff also need to maintain protective measures away from the bedside.
Authors: Steven He; Anthony Hecimovic; Vesna Matijasevic; Ha Thi Mai; Linda Heslop; Jann Foster; Kate E Alexander; Naru Pal; Evan Alexandrou; Patricia M Davidson; Steven A Frost Journal: J Clin Nurs Date: 2021-09-27 Impact factor: 4.423
Authors: Hayley Colton; David Hodgson; Hailey Hornsby; Rebecca Brown; Joanne Mckenzie; Kirsty L Bradley; Cameron James; Benjamin B Lindsey; Sarah Birch; Louise Marsh; Steven Wood; Martin Bayley; Gary Dickson; David C James; Martin J Nicklin; Jon R Sayers; Domen Zafred; Sarah L Rowland-Jones; Goura Kudesia; Adam Kucharski; Thomas C Darton; Thushan I de Silva; Paul J Collini Journal: Wellcome Open Res Date: 2022-06-10
Authors: Alexander J Parker; Monalisa Mishra; Pooja Tiwary; Mike Sharman; Manu Priya-Sharma; Alastair Duncan; Mohan Shanmugam; Kailash Bhatia; Catherine Fullwood; Andrew D Martin; Anthony Wilson Journal: Crit Care Explor Date: 2021-12-03
Authors: Edward Mullins; Ruth McCabe; Sheila M Bird; Paul Randell; Marcus J Pond; Lesley Regan; Eleanor Parker; Myra McClure; Christl A Donnelly Journal: PLoS One Date: 2022-09-02 Impact factor: 3.752
Authors: David Hodgson; Hayley Colton; Hailey Hornsby; Rebecca Brown; Joanne Mckenzie; Kirsty L Bradley; Cameron James; Benjamin B Lindsey; Sarah Birch; Louise Marsh; Steven Wood; Martin Bayley; Gary Dickson; David C James; Martin J H Nicklin; Jon R Sayers; Domen Zafred; Sarah L Rowland-Jones; Goura Kudesia; Adam Kucharski; Thomas C Darton; Thushan I de Silva; Paul J Collini Journal: medRxiv Date: 2021-07-08