Literature DB >> 33511368

SIMON: Open-Source Knowledge Discovery Platform.

Adriana Tomic1,2, Ivan Tomic3, Levi Waldron4,5, Ludwig Geistlinger4,5, Max Kuhn6, Rachel L Spreng7, Lindsay C Dahora7, Kelly E Seaton7, Georgia Tomaras7, Jennifer Hill1, Niharika A Duggal8, Ross D Pollock9, Norman R Lazarus9, Stephen D R Harridge9, Janet M Lord8,10, Purvesh Khatri2,11, Andrew J Pollard1, Mark M Davis2,12,13.   

Abstract

Data analysis and knowledge discovery has become more and more important in biology and medicine with the increasing complexity of biological datasets, but the necessarily sophisticated programming skills and in-depth understanding of algorithms needed pose barriers to most biologists and clinicians to perform such research. We have developed a modular open-source software, SIMON, to facilitate the application of 180+ state-of-the-art machine-learning algorithms to high-dimensional biomedical data. With an easy-to-use graphical user interface, standardized pipelines, and automated approach for machine learning and other statistical analysis methods, SIMON helps to identify optimal algorithms and provides a resource that empowers non-technical and technical researchers to identify crucial patterns in biomedical data.
© 2020 The Authors.

Entities:  

Keywords:  artificial intelligence; autoML; bioinformatics; computational biology; data mining; data science; machine learning; software; systems biology

Year:  2021        PMID: 33511368      PMCID: PMC7815964          DOI: 10.1016/j.patter.2020.100178

Source DB:  PubMed          Journal:  Patterns (N Y)        ISSN: 2666-3899


  41 in total

1.  Accessible, curated metagenomic data through ExperimentHub.

Authors:  Edoardo Pasolli; Lucas Schiffer; Paolo Manghi; Audrey Renson; Valerie Obenchain; Duy Tin Truong; Francesco Beghini; Faizan Malik; Marcel Ramos; Jennifer B Dowd; Curtis Huttenhower; Martin Morgan; Nicola Segata; Levi Waldron
Journal:  Nat Methods       Date:  2017-10-31       Impact factor: 28.547

2.  Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes.

Authors:  Evan W Newell; Natalia Sigal; Sean C Bendall; Garry P Nolan; Mark M Davis
Journal:  Immunity       Date:  2012-01-27       Impact factor: 31.745

Review 3.  Machine learning applications in genetics and genomics.

Authors:  Maxwell W Libbrecht; William Stafford Noble
Journal:  Nat Rev Genet       Date:  2015-05-07       Impact factor: 53.242

4.  Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry.

Authors:  Amir Horowitz; Dara M Strauss-Albee; Michael Leipold; Jessica Kubo; Neda Nemat-Gorgani; Ozge C Dogan; Cornelia L Dekker; Sally Mackey; Holden Maecker; Gary E Swan; Mark M Davis; Paul J Norman; Lisbeth A Guethlein; Manisha Desai; Peter Parham; Catherine A Blish
Journal:  Sci Transl Med       Date:  2013-10-23       Impact factor: 17.956

5.  Potential of fecal microbiota for early-stage detection of colorectal cancer.

Authors:  Georg Zeller; Julien Tap; Anita Y Voigt; Shinichi Sunagawa; Jens Roat Kultima; Paul I Costea; Aurélien Amiot; Jürgen Böhm; Francesco Brunetti; Nina Habermann; Rajna Hercog; Moritz Koch; Alain Luciani; Daniel R Mende; Martin A Schneider; Petra Schrotz-King; Christophe Tournigand; Jeanne Tran Van Nhieu; Takuji Yamada; Jürgen Zimmermann; Vladimir Benes; Matthias Kloor; Cornelia M Ulrich; Magnus von Knebel Doeberitz; Iradj Sobhani; Peer Bork
Journal:  Mol Syst Biol       Date:  2014-11-28       Impact factor: 11.429

6.  A 20-Gene Set Predictive of Progression to Severe Dengue.

Authors:  Makeda Robinson; Timothy E Sweeney; Rina Barouch-Bentov; Malaya Kumar Sahoo; Larry Kalesinskas; Francesco Vallania; Ana Maria Sanz; Eliana Ortiz-Lasso; Ludwig Luis Albornoz; Fernando Rosso; Jose G Montoya; Benjamin A Pinsky; Purvesh Khatri; Shirit Einav
Journal:  Cell Rep       Date:  2019-01-29       Impact factor: 9.423

7.  Severity Index for Suspected Arbovirus (SISA): Machine learning for accurate prediction of hospitalization in subjects suspected of arboviral infection.

Authors:  Rachel Sippy; Daniel F Farrell; Daniel A Lichtenstein; Ryan Nightingale; Megan A Harris; Joseph Toth; Paris Hantztidiamantis; Nicholas Usher; Cinthya Cueva Aponte; Julio Barzallo Aguilar; Anthony Puthumana; Christina D Lupone; Timothy Endy; Sadie J Ryan; Anna M Stewart Ibarra
Journal:  PLoS Negl Trop Dis       Date:  2020-02-14

Review 8.  Machine learning applications in cancer prognosis and prediction.

Authors:  Konstantina Kourou; Themis P Exarchos; Konstantinos P Exarchos; Michalis V Karamouzis; Dimitrios I Fotiadis
Journal:  Comput Struct Biotechnol J       Date:  2014-11-15       Impact factor: 7.271

9.  Assessment of Validity of a Blood-Based 3-Gene Signature Score for Progression and Diagnosis of Tuberculosis, Disease Severity, and Treatment Response.

Authors:  Hayley C Warsinske; Aditya M Rao; Flora M F Moreira; Paulo Cesar P Santos; Andrew B Liu; Madeleine Scott; Stephaus T Malherbe; Katharina Ronacher; Gerhard Walzl; Jill Winter; Timothy E Sweeney; Julio Croda; Jason R Andrews; Purvesh Khatri
Journal:  JAMA Netw Open       Date:  2018-10-05

10.  Combining immunoprofiling with machine learning to assess the effects of adjuvant formulation on human vaccine-induced immunity.

Authors:  Sidhartha Chaudhury; Elizabeth H Duncan; Tanmaya Atre; Sheetij Dutta; Michele D Spring; Wolfgang W Leitner; Elke S Bergmann-Leitner
Journal:  Hum Vaccin Immunother       Date:  2019-10-07       Impact factor: 3.452

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  3 in total

1.  Evaluating the Immune Response in Treatment-Naive Hospitalised Patients With Influenza and COVID-19.

Authors:  Jelmer Legebeke; Jenny Lord; Rebekah Penrice-Randal; Andres F Vallejo; Stephen Poole; Nathan J Brendish; Xiaofeng Dong; Catherine Hartley; John W Holloway; Jane S Lucas; Anthony P Williams; Gabrielle Wheway; Fabio Strazzeri; Aaron Gardner; James P R Schofield; Paul J Skipp; Julian A Hiscox; Marta E Polak; Tristan W Clark; Diana Baralle
Journal:  Front Immunol       Date:  2022-05-19       Impact factor: 8.786

Review 2.  Systems Immunology: Revealing Influenza Immunological Imprint.

Authors:  Adriana Tomic; Andrew J Pollard; Mark M Davis
Journal:  Viruses       Date:  2021-05-20       Impact factor: 5.048

3.  Divergent trajectories of antiviral memory after SARS-CoV-2 infection.

Authors:  Adriana Tomic; Donal T Skelly; Ane Ogbe; Daniel O'Connor; Paul Klenerman; Eleanor Barnes; Christina Dold; Susanna J Dunachie; Matthew Pace; Emily Adland; Frances Alexander; Mohammad Ali; Kirk Allott; M Azim Ansari; Sandra Belij-Rammerstorfer; Sagida Bibi; Luke Blackwell; Anthony Brown; Helen Brown; Breeze Cavell; Elizabeth A Clutterbuck; Thushan de Silva; David Eyre; Sheila Lumley; Amy Flaxman; James Grist; Carl-Philipp Hackstein; Rachel Halkerston; Adam C Harding; Jennifer Hill; Tim James; Cecilia Jay; Síle A Johnson; Barbara Kronsteiner; Yolanda Lie; Aline Linder; Stephanie Longet; Spyridoula Marinou; Philippa C Matthews; Jack Mellors; Christos Petropoulos; Patpong Rongkard; Cynthia Sedik; Laura Silva-Reyes; Holly Smith; Lisa Stockdale; Stephen Taylor; Stephen Thomas; Timothy Tipoe; Lance Turtle; Vinicius Adriano Vieira; Terri Wrin; Andrew J Pollard; Teresa Lambe; Chris P Conlon; Katie Jeffery; Simon Travis; Philip Goulder; John Frater; Alex J Mentzer; Lizzie Stafford; Miles W Carroll; William S James
Journal:  Nat Commun       Date:  2022-03-10       Impact factor: 14.919

  3 in total

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