Ana Catarina Silva1,2,3, Cassilda Pereira1,2, Ana Catarina R G Fonseca1,2, Perpétua Pinto-do-Ó1,2,4, Diana S Nascimento1,2,4. 1. i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal. 2. INEB - Instituto Nacional de Engenharia Biomédica, Universidade do Porto, Porto, Portugal. 3. Gladstone Institutes, San Francisco, CA, United States. 4. ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal.
Abstract
The extracellular matrix (ECM) is an essential component of the heart that imparts fundamental cellular processes during organ development and homeostasis. Most cardiovascular diseases involve severe remodeling of the ECM, culminating in the formation of fibrotic tissue that is deleterious to organ function. Treatment schemes effective at managing fibrosis and promoting physiological ECM repair are not yet in reach. Of note, the composition of the cardiac ECM changes significantly in a short period after birth, concurrent with the loss of the regenerative capacity of the heart. This highlights the importance of understanding ECM composition and function headed for the development of more efficient therapies. In this review, we explore the impact of ECM alterations, throughout heart ontogeny and disease, on cardiac cells and debate available approaches to deeper insights on cell-ECM interactions, toward the design of new regenerative therapies.
The extn class="Chemical">racellular matrix (ECM) is an essential componpan>ent of the heart tn class="Chemical">hat imparts fundamental cellular processes during organ development and homeostasis. Most pan class="Disease">cardiovascular diseases involve severe remodeling of the ECM, culminating in the formation of fibrotic tissue that is deleterious to organ function. Treatment schemes effective at managing pan class="Disease">fibrosis and promoting physiological ECM repair are not yet in reach. Of note, the composition of the cardiac ECM changes significantly in a short period after birth, concurrent with the loss of the regenerative capacity of the heart. This highlights the importance of understanding ECM composition and function headed for the development of more efficient therapies. In this review, we explore the impact of ECM alterations, throughout heart ontogeny and disease, on cardiac cells and debate available approaches to deeper insights on cell-ECM interactions, toward the design of new regenerative therapies.
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