Laurent Irakoze1,2,3, Astère Manirakiza4, Yunqi Zhang3, Juncheng Liu3, Jiayu Li3, Liliane Nkengurutse5, Shuhua Deng6, Xiaoqiu Xiao7,8. 1. Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 2. Kamenge Military Hospital, Ministry of Public Health and Fighting AIDS, Bujumbura, Burundi. 3. The Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 4. Department of Oncology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 5. Ministry of Public Health and Fighting AIDS, Epidemiological Emergency Service, Bujumbura, Burundi. 6. Department of Respiratory Medicine, Chengdu First People's Hospital, Chengdu, China. 7. Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China, 3189983504@qq.com. 8. The Chongqing Key Laboratory of Translational Medicine in Major Metabolic Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China, 3189983504@qq.com.
Abstract
BACKGROUND: The metabolic syndrome (MetS) represents a clustering of risk factors for cardiovascular diseases that includes abdominal obesity, hypertension, dyslipidemia, and insulin resistance. OBJECTIVES: The objective of this study was to reassess the parent-offspring association of MetS since the available findings are still controversial. METHODS: The Cochrane Library, PubMed, Embase, and Web of Science databases were searched to identify relevant articles. All studies comparing MetS status between the offspring of parents with MetS and offspring of parents without MetS were included in the analysis. RESULTS: A total of 9 studies met the inclusion criteria and they were analyzed. Offspring of at least 1 parent with MetS had a higher risk of MetS (OR 3.88, 95% CI 2.58-5.83, p < 0.001). Sons and daughters of fathers with MetS both had a higher risk of MetS (OR 2.31, 95% CI 1.70-3.12, p < 0.001, and OR 1.73, 95% CI 1.37-2.18, p < 0.001, respectively). Sons and daughters of mothers with MetS both had a higher risk of MetS (OR 1.95, 95% CI 1.37-2.76, p = 0.0002, and OR 1.91, 95% CI 1.54-2.35, p < 0.001, respectively). CONCLUSION: This meta-analysis showed that there is a higher risk of MetS in the offspring of parents with MetS. However, there was no differential association of MetS according to gender and/or age of the offspring.
BACKGROUND: The metabolic syndrome (MetS) represents a clustering of risk factors for cardiovascular diseases that includes abdominal obesity, hypertension, dyslipidemia, and insulin resistance. OBJECTIVES: The objective of this study was to reassess the parent-offspring association of MetS since the available findings are still controversial. METHODS: The Cochrane Library, PubMed, Embase, and Web of Science databases were searched to identify relevant articles. All studies comparing MetS status between the offspring of parents with MetS and offspring of parents without MetS were included in the analysis. RESULTS: A total of 9 studies met the inclusion criteria and they were analyzed. Offspring of at least 1 parent with MetS had a higher risk of MetS (OR 3.88, 95% CI 2.58-5.83, p < 0.001). Sons and daughters of fathers with MetS both had a higher risk of MetS (OR 2.31, 95% CI 1.70-3.12, p < 0.001, and OR 1.73, 95% CI 1.37-2.18, p < 0.001, respectively). Sons and daughters of mothers with MetS both had a higher risk of MetS (OR 1.95, 95% CI 1.37-2.76, p = 0.0002, and OR 1.91, 95% CI 1.54-2.35, p < 0.001, respectively). CONCLUSION: This meta-analysis showed that there is a higher risk of MetS in the offspring of parents with MetS. However, there was no differential association of MetS according to gender and/or age of the offspring.
Authors: A Bellia; E Giardina; D Lauro; M Tesauro; G Di Fede; G Cusumano; M Federici; G B Rini; G Novelli; R Lauro; P Sbraccia Journal: Nutr Metab Cardiovasc Dis Date: 2009-02-06 Impact factor: 4.222
Authors: F Belva; M Bonduelle; S Provyn; R C Painter; H Tournaye; M Roelants; J De Schepper Journal: Int J Endocrinol Date: 2018-05-03 Impact factor: 3.257