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Literature DB >> 33507143

Targeting novel structural and functional features of coronavirus protease nsp5 (3CL^pro, M^pro) in the age of COVID-19.

Molly K Roe¹, Nathan A Junod¹, Audrey R Young¹, Dia C Beachboard², Christopher C Stobart¹.

Abstract

Coronavirus protease nsp5 (Mpro, 3CLpro) remains a primary target for coronavirus therapeutics due to its indispensable and conserved role in the proteolytic processing of the viral replicase polyproteins. In this review, we discuss the diversity of known coronaviruses, the role of nsp5 in coronavirus biology, and the structure and function of this protease across the diversity of known coronaviruses, and evaluate past and present efforts to develop inhibitors to the nsp5 protease with a particular emphasis on new and mostly unexplored potential targets of inhibition. With the recent emergence of pandemic SARS-CoV-2, this review provides novel and potentially innovative strategies and directions to develop effective therapeutics against the coronavirus protease nsp5.

Entities: Disease Species

Keywords: 3CLpro; Coronavirus; inhibitors; nsp5; protease

Mesh：

Substances：

Year: 2021 PMID： 33507143 DOI： 10.1099/jgv.0.001558

Source DB: PubMed Journal: J Gen Virol ISSN： 0022-1317 Impact factor: 3.891

18 in total

Review 1. Identifying Markers of Emerging SARS-CoV-2 Variants in Patients With Secondary Immunodeficiency.

Authors: Nathan M Markarian; Gaël Galli; Dhanesh Patel; Mark Hemmings; Priya Nagpal; Albert M Berghuis; Levon Abrahamyan; Silvia M Vidal
Journal: Front Microbiol Date: 2022-07-01 Impact factor: 6.064

Review 2. Network for network concept offers new insights into host- SARS-CoV-2 protein interactions and potential novel targets for developing antiviral drugs.

Authors: Neda Eskandarzade; Abozar Ghorbani; Samira Samarfard; Jose Diaz; Pietro H Guzzi; Niloofar Fariborzi; Ahmad Tahmasebi; Keramatollah Izadpanah
Journal: Comput Biol Med Date: 2022-04-30 Impact factor: 6.698

3. SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response.

Authors: Yongzhen Liu; Chao Qin; Youliang Rao; Chau Ngo; Joshua J Feng; Jun Zhao; Shu Zhang; Ting-Yu Wang; Jessica Carriere; Ali Can Savas; Mehrnaz Zarinfar; Stephanie Rice; Hanging Yang; Weiming Yuan; Julio A Camarero; Jianhua Yu; Xiaojiang S Chen; Chao Zhang; Pinghui Feng
Journal: mBio Date: 2021-09-21 Impact factor: 7.786

4. SARS-CoV-2 main protease suppresses type I interferon production by preventing nuclear translocation of phosphorylated IRF3.

Authors: Sin-Yee Fung; Kam-Leung Siu; Huayue Lin; Man Lung Yeung; Dong-Yan Jin
Journal: Int J Biol Sci Date: 2021-04-10 Impact factor: 6.580

5. Pre-Steady-State Kinetics of the SARS-CoV-2 Main Protease as a Powerful Tool for Antiviral Drug Discovery.

Authors: Maria Yu Zakharova; Alexandra A Kuznetsova; Victoria I Uvarova; Anastasiia D Fomina; Liubov I Kozlovskaya; Elena N Kaliberda; Inna N Kurbatskaia; Ivan V Smirnov; Anatoly A Bulygin; Vera D Knorre; Olga S Fedorova; Alexandre Varnek; Dmitry I Osolodkin; Aydar A Ishmukhametov; Alexey M Egorov; Alexander G Gabibov; Nikita A Kuznetsov
Journal: Front Pharmacol Date: 2021-12-06 Impact factor: 5.810

Review 9. Structure-Function Characteristics of SARS-CoV-2 Proteases and Their Potential Inhibitors from Microbial Sources.

Authors: Rafida Razali; Haslina Asis; Cahyo Budiman
Journal: Microorganisms Date: 2021-11-30

10. Analysis of SARS-CoV-2 mutations in the main viral protease (NSP5) and its implications on the vaccine designing strategies.

Authors: Niti Yashvardhini; Amit Kumar; Deepak Kumar Jha
Journal: Vacunas Date: 2021-12-03