Zhangcheng Liu1,2, Chi Chen3, Fuxun Yu4, Dongbo Yuan1, Wei Wang1, Ke Jiao1, Shengbang Yang1,5, Yongqiang Zhang1, Yong Wang2, Linhai Liu2, Huali Xu2, Yang Zhang2, Guohua Zhu1, Bin Hu1, Jianguo Zhu1,5. 1. Department of Urology, Guizhou Provincial People's Hospital, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province 550002, China. 2. Department of Urology, The Second People's Hospital of Neijiang, Neijiang, Sichuan Province 641000, China. 3. Department of Immunology and Microbiology, Guiyang College of Traditional Chinese Medicine, Guiyang, Guizhou Province 550001, China. 4. The National Health Commission's Key Laboratory of Immunological Pulmonary Disease, Guizhou Provincial People's Hospital, Guiyang, Guizhou Province 550002, China. 5. Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First Municipal People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong Province 510180, China.
Abstract
BACKGROUND: There is increasing evidence that dietary intake of sugars may be a risk factor for prostate cancer (PCa) and elevate the concentration of serum prostate-specific antigen (PSA). However, there is limited evidence of the correlation between total dietary intake of sugars and serum PSA concentrations for adult American males. Herein, we evaluated the association between total dietary intake of sugars and serum PSA concentrations in men without a malignant tumor diagnosis in the United States (US) National Health and Nutrition Examination Survey (NHANES) database. Material and Methods. In this secondary data analysis, a total of 6,403 men aged ≥40 years and without malignant tumor history were included from 2003 to 2010. The independent variable of this study was the total dietary intake of sugars, and the dependent variable was serum PSA concentrations. Covariates included dietary, comorbidity, physical examination, and demographic data. RESULTS: The average age of participants included in this study was 58.1 years (±13.6). After adjusting for the dietary, comorbidity, physical examination, and demographic data, we observed that a dietary intake increase of one gram of total dietary intake of sugars was associated with an increase of serum PSA concentrations by 0.003 ng/mL (after log2 transformed, 95% CI: 0.001 to 0.005) with a P value for trend less than 0.05. Sensitivity analysis using the generalized additive model (GAM) supported the linear association between total dietary intake of sugars and serum PSA concentrations. CONCLUSION: The total dietary intake of sugars is independently and positively associated with serum PSA concentrations in adult American males who are without a personal history of malignant tumors.
BACKGROUND: There is increasing evidence that dietary intake of sugars may be a risk factor for prostate cancer (PCa) and elevate the concentration of serum prostate-specific antigen (PSA). However, there is limited evidence of the correlation between total dietary intake of sugars and serum PSA concentrations for adult American males. Herein, we evaluated the association between total dietary intake of sugars and serum PSA concentrations in men without a malignant tumor diagnosis in the United States (US) National Health and Nutrition Examination Survey (NHANES) database. Material and Methods. In this secondary data analysis, a total of 6,403 men aged ≥40 years and without malignant tumor history were included from 2003 to 2010. The independent variable of this study was the total dietary intake of sugars, and the dependent variable was serum PSA concentrations. Covariates included dietary, comorbidity, physical examination, and demographic data. RESULTS: The average age of participants included in this study was 58.1 years (±13.6). After adjusting for the dietary, comorbidity, physical examination, and demographic data, we observed that a dietary intake increase of one gram of total dietary intake of sugars was associated with an increase of serum PSA concentrations by 0.003 ng/mL (after log2 transformed, 95% CI: 0.001 to 0.005) with a P value for trend less than 0.05. Sensitivity analysis using the generalized additive model (GAM) supported the linear association between total dietary intake of sugars and serum PSA concentrations. CONCLUSION: The total dietary intake of sugars is independently and positively associated with serum PSA concentrations in adult American males who are without a personal history of malignant tumors.
Authors: Richard J Johnson; Santos E Perez-Pozo; Yuri Y Sautin; Jacek Manitius; Laura Gabriela Sanchez-Lozada; Daniel I Feig; Mohamed Shafiu; Mark Segal; Richard J Glassock; Michiko Shimada; Carlos Roncal; Takahiko Nakagawa Journal: Endocr Rev Date: 2009-01-16 Impact factor: 19.871
Authors: Julius Gudmundsson; Jon K Sigurdsson; Lilja Stefansdottir; Bjarni A Agnarsson; Helgi J Isaksson; Olafur A Stefansson; Sigurjon A Gudjonsson; Daniel F Gudbjartsson; Gisli Masson; Michael L Frigge; Simon N Stacey; Patrick Sulem; Gisli H Halldorsson; Vinicius Tragante; Hilma Holm; Gudmundur I Eyjolfsson; Olof Sigurdardottir; Isleifur Olafsson; Thorvaldur Jonsson; Eirikur Jonsson; Rosa B Barkardottir; Rafn Hilmarsson; Folkert W Asselbergs; Gudmundur Geirsson; Unnur Thorsteinsdottir; Thorunn Rafnar; Gudmar Thorleifsson; Kari Stefansson Journal: Nat Commun Date: 2018-11-08 Impact factor: 14.919
Authors: Dragan Ilic; Mia Djulbegovic; Jae Hung Jung; Eu Chang Hwang; Qi Zhou; Anne Cleves; Thomas Agoritsas; Philipp Dahm Journal: BMJ Date: 2018-09-05