Background: Mounting evidence suggests SARS-CoV-2 may impact on host microbiota and gut inflammation, infecting intestinal epithelial cells. This possible link and its implications can be investigated by observing the effects of modulation of the microbial flora in patients with COVID-19. The aim of this study was to compare the rate of mortality, the need of ICU hospitalization and the length of hospitalization in patients with severe COVID-19 pneumonia who received the best available therapy (BAT) vs. patients treated with BAT and supplemented with oral bacteriotherapy. Methods: This retrospective, observational cohort study included 200 adults with severe COVID-19 pneumonia. All patients received therapeutic regimens including low molecular weight heparin plus one or more between hydroxychloroquine, azithromycin, antivirals, and Tocilizumab. Oral bacteriotherapy was used as complementary treatment. Results: Out of the 200 patients, 112 received BAT without oral bacteriotherapy, and 88 BAT with oral bacteriotherapy. Crude mortality was 22%. Eleven percent died in the group of patients treated with BAT plus oral bacteriotherapy vs. 30% subjects in the group of patients managed only with BAT (p < 0.001). By multivariate analysis, the age >65 years, CRP >41.8 mg/L, Platelets <150.000 mmc, and cardiovascular events were associated with the increased risk of mortality. Oral bacteriotherapy was an independent variable associated with a reduced risk for death. Despite large prospective trials are needed, this study highlights a possible role for oral bacteriotherapy in the management of patients hospitalized for COVID-19 pneumonia.
Background: Mounting evidence suggests SARS-CoV-2 may impact on host microbiota and gut inflammation, infecting intestinal epithelial cells. This possible link and its implications can be investigated by observing the effects of modulation of the microbial flora in patients with COVID-19. The aim of this study was to compare the rate of mortality, the need of ICU hospitalization and the length of hospitalization in patients with severe COVID-19 pneumonia who received the best available therapy (BAT) vs. patients treated with BAT and supplemented with oral bacteriotherapy. Methods: This retrospective, observational cohort study included 200 adults with severe COVID-19 pneumonia. All patients received therapeutic regimens including low molecular weight heparin plus one or more between hydroxychloroquine, azithromycin, antivirals, and Tocilizumab. Oral bacteriotherapy was used as complementary treatment. Results: Out of the 200 patients, 112 received BAT without oral bacteriotherapy, and 88 BAT with oral bacteriotherapy. Crude mortality was 22%. Eleven percent died in the group of patients treated with BAT plus oral bacteriotherapy vs. 30% subjects in the group of patients managed only with BAT (p < 0.001). By multivariate analysis, the age >65 years, CRP >41.8 mg/L, Platelets <150.000 mmc, and cardiovascular events were associated with the increased risk of mortality. Oral bacteriotherapy was an independent variable associated with a reduced risk for death. Despite large prospective trials are needed, this study highlights a possible role for oral bacteriotherapy in the management of patients hospitalized for COVID-19 pneumonia.
Authors: Brittany Seibert; C Joaquín Cáceres; Stivalis Cardenas-Garcia; Silvia Carnaccini; Ginger Geiger; Daniela S Rajao; Elizabeth Ottesen; Daniel R Perez Journal: Microbiol Spectr Date: 2021-08-11
Authors: Letizia Santinelli; Luca Laghi; Giuseppe Pietro Innocenti; Claudia Pinacchio; Paolo Vassalini; Luigi Celani; Alessandro Lazzaro; Cristian Borrazzo; Massimiliano Marazzato; Lorenzo Tarsitani; Alexia E Koukopoulos; Claudio M Mastroianni; Gabriella d'Ettorre; Giancarlo Ceccarelli Journal: Front Nutr Date: 2022-01-12
Authors: Pedro Gutiérrez-Castrellón; Tania Gandara-Martí; Ana T Abreu Y Abreu; Cesar D Nieto-Rufino; Eduardo López-Orduña; Irma Jiménez-Escobar; Carlos Jiménez-Gutiérrez; Gabriel López-Velazquez; Jordi Espadaler-Mazo Journal: Gut Microbes Date: 2022 Jan-Dec
Authors: Laura Linares-García; María E Cárdenas-Barragán; Winston Hernández-Ceballos; Carlos S Pérez-Solano; Alizon S Morales-Guzmán; Danielle S Miller; Max Schmulson Journal: J Clin Gastroenterol Date: 2022-04-01 Impact factor: 3.062