Literature DB >> 33505137

Application of Tucatinib and Trastuzumab: Dual Anti HER2 Therapy Against HER2 Positive Breast Cancer.

Sumanpreet Kaur1, Rajasri Bhattacharyya1, Dibyajyoti Banerjee1, Jaya Shukla2.   

Abstract

Synergism in action of tucatinib and trastumab is reported in breast cancer management. However, its molecular basis is yet to be determined. In this context we attempted to provide an explanation at the molecular level by performing in silico experimentation and coupling its result with already available published observations. Our study will provide basis for planning further experimental study for unravelling the truth. © Association of Clinical Biochemists of India 2019.

Entities:  

Keywords:  Breast cancer; Synergism; Trastumab; Tucatinib

Year:  2019        PMID: 33505137      PMCID: PMC7817741          DOI: 10.1007/s12291-019-00863-8

Source DB:  PubMed          Journal:  Indian J Clin Biochem        ISSN: 0970-1915


  5 in total

1.  Dual inhibition of HER2 in breast cancer treatment.

Authors:  Michael Gnant; Guenther G Steger
Journal:  Lancet       Date:  2012-01-17       Impact factor: 79.321

Review 2.  Targeting HER2 in other tumor types.

Authors:  S Scholl; P Beuzeboc; P Pouillart
Journal:  Ann Oncol       Date:  2001       Impact factor: 32.976

Review 3.  Mechanisms of resistance to anti-human epidermal growth factor receptor 2 agents in breast cancer.

Authors:  Toru Mukohara
Journal:  Cancer Sci       Date:  2010-09-06       Impact factor: 6.716

Review 4.  HER2-positive breast cancer: new therapeutic frontiers and overcoming resistance.

Authors:  Sonia Pernas; Sara M Tolaney
Journal:  Ther Adv Med Oncol       Date:  2019-03-19       Impact factor: 8.168

Review 5.  Genomic alterations of ERBB receptors in cancer: clinical implications.

Authors:  Rosalin Mishra; Ariella B Hanker; Joan T Garrett
Journal:  Oncotarget       Date:  2017-11-30
  5 in total
  1 in total

Review 1.  The efficacy of tucatinib-based therapeutic approaches for HER2-positive breast cancer.

Authors:  Zaid Sirhan; Anita Thyagarajan; Ravi P Sahu
Journal:  Mil Med Res       Date:  2022-07-13
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.