| Literature DB >> 33504811 |
Akinori Nishi1, Katsuya Ohbuchi2, Noriko Kaifuchi2, Chika Shimobori2, Hirotaka Kushida2, Masahiro Yamamoto2, Yoshihiro Kita3,4, Suzumi M Tokuoka4, Ayako Yachie5, Yukiko Matsuoka5, Hiroaki Kitano5.
Abstract
Lipid mediators are major factors in multiple biological functions and are strongly associated with disease. Recent lipidomics approaches have made it possible to analyze multiple metabolites and the associations of individual lipid mediators. Such systematic approaches have enabled us to identify key changes of biological relevance. Against this background, a knowledge-based pathway map of lipid mediators would be useful to visualize and understand the overall interactions of these factors. Here, we have built a precise map of lipid mediator metabolic pathways (LimeMap) to visualize the comprehensive profiles of lipid mediators that change dynamically in various disorders. We constructed the map by focusing on ω-3 and ω-6 fatty acid metabolites and their respective metabolic pathways, with manual curation of referenced information from public databases and relevant studies. Ultimately, LimeMap comprises 282 factors (222 mediators, and 60 enzymes, receptors, and ion channels) and 279 reactions derived from 102 related studies. Users will be able to modify the map and visualize measured data specific to their purposes using CellDesigner and VANTED software. We expect that LimeMap will contribute to elucidating the comprehensive functional relationships and pathways of lipid mediators.Entities:
Year: 2021 PMID： 33504811 PMCID： PMC7840682 DOI： 10.1038/s41540-020-00163-5
Source DB: PubMed Journal: NPJ Syst Biol Appl ISSN： 2056-7189