Matthew Paradise1, John D Crawford2, Ben C P Lam2, Wei Wen2, Nicole A Kochan2, Steve Makkar2, Laughlin Dawes2, Julian Trollor2, Brian Draper2, Henry Brodaty2, Perminder S Sachdev2. 1. From the Centre for Healthy Brain Ageing (CHeBA) (M.P., J.D.C., B.C.P.L., W.W., N.A.K., S.M., J.T., B.D., H.B., P.S.S.), School of Psychiatry, UNSW Medicine, University of New South Wales; Neuropsychiatric Institute (P.S.S.), The Prince of Wales Hospital (L.D., B.D., H.B.) ; and Department of Developmental Disability Neuropsychiatry, School of Psychiatry (J.T.), UNSW Sydney, Australia. z3495052@ad.unsw.edu.au. 2. From the Centre for Healthy Brain Ageing (CHeBA) (M.P., J.D.C., B.C.P.L., W.W., N.A.K., S.M., J.T., B.D., H.B., P.S.S.), School of Psychiatry, UNSW Medicine, University of New South Wales; Neuropsychiatric Institute (P.S.S.), The Prince of Wales Hospital (L.D., B.D., H.B.) ; and Department of Developmental Disability Neuropsychiatry, School of Psychiatry (J.T.), UNSW Sydney, Australia.
Abstract
OBJECTIVE: To determine whether severe perivascular space (PVS) dilation is associated with longitudinal cognitive decline and incident dementia over 4 and 8 years, respectively, we analyzed data from a prospective cohort study. METHODS: A total of 414 community-dwelling older adults aged 72-92 years were assessed at baseline and biennially for up to 8 years, with cognitive assessments, consensus dementia diagnoses, and 3T MRI. The numbers of PVS in 2 representative slices in the basal ganglia (BG) and centrum semiovale (CSO) were counted and severe PVS pathology defined as the top quartile. The effects of severe PVS pathology in either region or both regions and those with severe BG PVS and severe CSO PVS were examined. White matter hyperintensity volume, cerebral microbleed number, and lacune number were calculated. RESULTS: Participants with severe PVS pathology in both regions or in the CSO alone had greater decline in global cognition over 4 years, even after adjustment for the presence of other small vessel disease neuroimaging markers. The presence of severe PVS pathology in both regions was an independent predictor of dementia across 8 years (odds ratio 2.91, 95% confidence interval 1.43-5.95, p = 0.003). The presence of severe PVS pathology in all groups examined was associated with greater dementia risk at either year 4 or 6. CONCLUSIONS: Severe PVS pathology is a marker for increased risk of cognitive decline and dementia, independent of other small vessel disease markers. The differential cognitive associations for BG and CSO PVS may represent differences in their underlying pathology.
OBJECTIVE: To determine whether severe perivascular space (PVS) dilation is associated with longitudinal cognitive decline and incident dementia over 4 and 8 years, respectively, we analyzed data from a prospective cohort study. METHODS: A total of 414 community-dwelling older adults aged 72-92 years were assessed at baseline and biennially for up to 8 years, with cognitive assessments, consensus dementia diagnoses, and 3T MRI. The numbers of PVS in 2 representative slices in the basal ganglia (BG) and centrum semiovale (CSO) were counted and severe PVS pathology defined as the top quartile. The effects of severe PVS pathology in either region or both regions and those with severe BG PVS and severe CSO PVS were examined. White matter hyperintensity volume, cerebral microbleed number, and lacune number were calculated. RESULTS: Participants with severe PVS pathology in both regions or in the CSO alone had greater decline in global cognition over 4 years, even after adjustment for the presence of other small vessel disease neuroimaging markers. The presence of severe PVS pathology in both regions was an independent predictor of dementia across 8 years (odds ratio 2.91, 95% confidence interval 1.43-5.95, p = 0.003). The presence of severe PVS pathology in all groups examined was associated with greater dementia risk at either year 4 or 6. CONCLUSIONS: Severe PVS pathology is a marker for increased risk of cognitive decline and dementia, independent of other small vessel disease markers. The differential cognitive associations for BG and CSO PVS may represent differences in their underlying pathology.
Authors: Erik von Elm; Douglas G Altman; Matthias Egger; Stuart J Pocock; Peter C Gøtzsche; Jan P Vandenbroucke Journal: J Clin Epidemiol Date: 2008-04 Impact factor: 6.437
Authors: Shanna L Burke; Tianyan Hu; Mitra Naseh; Nicole M Fava; Janice O'Driscoll; Daniel Alvarez; Linda B Cottler; Ranjan Duara Journal: Aging Clin Exp Res Date: 2018-12-10 Impact factor: 3.636
Authors: Saima Hilal; Chuen Seng Tan; Hieab H H Adams; Mohamad Habes; Vincent Mok; Narayanaswamy Venketasubramanian; Edith Hofer; M Kamran Ikram; Jill Abrigo; Meike W Vernooij; Christopher Chen; Norbert Hosten; Henry Volzke; Hans J Grabe; Reinhold Schmidt; M Arfan Ikram Journal: Neurology Date: 2018-08-01 Impact factor: 9.910
Authors: Sara Shams; Juha Martola; Andreas Charidimou; Mykol Larvie; Tobias Granberg; Mana Shams; Maria Kristoffersen-Wiberg; Lars-Olof Wahlund Journal: J Am Heart Assoc Date: 2017-09-22 Impact factor: 5.501
Authors: Joanna M Wardlaw; Eric E Smith; Geert J Biessels; Charlotte Cordonnier; Franz Fazekas; Richard Frayne; Richard I Lindley; John T O'Brien; Frederik Barkhof; Oscar R Benavente; Sandra E Black; Carol Brayne; Monique Breteler; Hugues Chabriat; Charles Decarli; Frank-Erik de Leeuw; Fergus Doubal; Marco Duering; Nick C Fox; Steven Greenberg; Vladimir Hachinski; Ingo Kilimann; Vincent Mok; Robert van Oostenbrugge; Leonardo Pantoni; Oliver Speck; Blossom C M Stephan; Stefan Teipel; Anand Viswanathan; David Werring; Christopher Chen; Colin Smith; Mark van Buchem; Bo Norrving; Philip B Gorelick; Martin Dichgans Journal: Lancet Neurol Date: 2013-08 Impact factor: 44.182
Authors: Young Min Choe; Hyewon Baek; Hyo Jung Choi; Min Soo Byun; Dahyun Yi; Bo Kyung Sohn; Chul-Ho Sohn; Dong Young Lee Journal: Neurology Date: 2022-06-28 Impact factor: 11.800
Authors: Timothy J Libecap; Valentinos Zachariou; Christopher E Bauer; Donna M Wilcock; Gregory A Jicha; Flavius D Raslau; Brian T Gold Journal: Front Neurol Date: 2022-07-01 Impact factor: 4.086
Authors: Tatjana Rundek; Magdalena Tolea; Taylor Ariko; Eric A Fagerli; Christian J Camargo Journal: Neurotherapeutics Date: 2021-12-22 Impact factor: 6.088
Authors: Jeremy N Ford; Qihao Zhang; Elizabeth M Sweeney; Alexander E Merkler; Mony J de Leon; Ajay Gupta; Thanh D Nguyen; Jana Ivanidze Journal: Front Aging Neurosci Date: 2022-04-08 Impact factor: 5.702