Literature DB >> 33504013

Neovascular Macular Degeneration: A Review of Etiology, Risk Factors, and Recent Advances in Research and Therapy.

Arunbalaji Pugazhendhi1, Margaret Hubbell1, Pooja Jairam2, Balamurali Ambati1.   

Abstract

Neovascular age-related macular degeneration (exudative or wet AMD) is a prevalent, progressive retinal degenerative macular disease that is characterized by neovascularization of the choroid, mainly affecting the elderly population causing gradual vision impairment. Risk factors such as age, race, genetics, iris color, smoking, drinking, BMI, and diet all play a part in nvAMD's progression, with anti-vascular endothelial growth factor (anti-VEGF) therapy being the mainstay of treatment. Current therapeutic advancements slow the progression of the disease but do not cure or reverse its course. Newer therapies such as gene therapies, Rho-kinase inhibitors, and levodopa offer potential new targets for treatment.

Entities:  

Keywords:  age-related macular degeneration; anti-VEGF; etiopathogenesis; future advancements; gene-therapy; neovascular age-related macular degeneration; risk factors

Mesh：

Substances：

Year:  2021        PMID： 33504013      PMCID： PMC7866170          DOI： 10.3390/ijms22031170

Source DB:  PubMed          Journal:  Int J Mol Sci        ISSN： 1422-0067            Impact factor:   5.923


  246 in total

1.  Adherence to a Mediterranean diet, genetic susceptibility, and progression to advanced macular degeneration: a prospective cohort study.

Authors:  Bénédicte M J Merle; Rachel E Silver; Bernard Rosner; Johanna M Seddon
Journal:  Am J Clin Nutr       Date:  2015-10-21       Impact factor: 7.045

2.  Ranibizumab for neovascular age-related macular degeneration.

Authors:  Philip J Rosenfeld; David M Brown; Jeffrey S Heier; David S Boyer; Peter K Kaiser; Carol Y Chung; Robert Y Kim
Journal:  N Engl J Med       Date:  2006-10-05       Impact factor: 91.245

3.  Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1.

Authors:  Jun Cai; Wen G Jiang; Maria B Grant; Mike Boulton
Journal:  J Biol Chem       Date:  2005-12-08       Impact factor: 5.157

4.  Simultaneous Inhibition of Angiopoietin-2 and Vascular Endothelial Growth Factor-A with Faricimab in Diabetic Macular Edema: BOULEVARD Phase 2 Randomized Trial.

Authors:  Jayashree Sahni; Sunil S Patel; Pravin U Dugel; Arshad M Khanani; Chirag D Jhaveri; Charles C Wykoff; Vrinda S Hershberger; Meike Pauly-Evers; Shamil Sadikhov; Piotr Szczesny; Dietmar Schwab; Everson Nogoceke; Aaron Osborne; Robert Weikert; Sascha Fauser
Journal:  Ophthalmology       Date:  2019-03-21       Impact factor: 12.079

5.  The relationship between iris color, hair color, and skin sun sensitivity and the 10-year incidence of age-related maculopathy: the Beaver Dam Eye Study.

Authors:  Sandra C Tomany; Ronald Klein; Barbara E K Klein
Journal:  Ophthalmology       Date:  2003-08       Impact factor: 12.079

Review 6.  Overweight, Obesity, and Risk of Age-Related Macular Degeneration.

Authors:  Qian-Yu Zhang; Li-Jun Tie; Shan-Shan Wu; Pei-Lin Lv; Hong-Wei Huang; Wei-Qing Wang; Hui Wang; Le Ma
Journal:  Invest Ophthalmol Vis Sci       Date:  2016-03       Impact factor: 4.799

Review 7.  Nicotine and pathological angiogenesis.

Authors:  Jieun Lee; John P Cooke
Journal:  Life Sci       Date:  2012-07-13       Impact factor: 5.037

8.  Synthesis and secretion of vascular permeability factor/vascular endothelial growth factor by human retinal pigment epithelial cells.

Authors:  A P Adamis; D T Shima; K T Yeo; T K Yeo; L F Brown; B Berse; P A D'Amore; J Folkman
Journal:  Biochem Biophys Res Commun       Date:  1993-06-15       Impact factor: 3.575

9.  Macular pigment and its contribution to vision.

Authors:  Ekaterina Loskutova; John Nolan; Alan Howard; Stephen Beatty
Journal:  Nutrients       Date:  2013-05-29       Impact factor: 5.717

10.  Light action spectrum on oxidative stress and mitochondrial damage in A2E-loaded retinal pigment epithelium cells.

Authors:  Mélanie Marie; Karine Bigot; Claire Angebault; Coralie Barrau; Pauline Gondouin; Delphine Pagan; Stéphane Fouquet; Thierry Villette; José-Alain Sahel; Guy Lenaers; Serge Picaud
Journal:  Cell Death Dis       Date:  2018-02-19       Impact factor: 8.469
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  12 in total

Review 1.  Biomarkers as Predictive Factors of Anti-VEGF Response.

Authors:  Miriam Bobadilla; Ana Pariente; Ana I Oca; Rafael Peláez; Álvaro Pérez-Sala; Ignacio M Larráyoz
Journal:  Biomedicines       Date:  2022-04-26

2.  Activated Protein C (APC) and 3K3A-APC-Induced Regression of Choroidal Neovascularization (CNV) Is Accompanied by Vascular Endothelial Growth Factor (VEGF) Reduction.

Authors:  Tami Livnat; Yehonatan Weinberger; José A Fernández; Alaa Bashir; Gil Ben-David; Dahlia Palevski; Sarina Levy-Mendelovich; Gili Kenet; Ivan Budnik; Yael Nisgav; John H Griffin; Dov Weinberger
Journal:  Biomolecules       Date:  2021-02-26

3.  Assessment of a New Nanostructured Microemulsion System for Ocular Delivery of Sorafenib to Posterior Segment of the Eye.

Authors:  Manuela Santonocito; Cristina Zappulla; Santa Viola; Luca Rosario La Rosa; Elena Solfato; Ilenia Abbate; Valeria Tarallo; Ivana Apicella; Chiara Bianca Maria Platania; Grazia Maugeri; Velia D'Agata; Claudio Bucolo; Sandro De Falco; Maria Grazia Mazzone; Francesco Giuliano
Journal:  Int J Mol Sci       Date:  2021-04-22       Impact factor: 5.923

Review 4.  Effectiveness of Current Treatments for Wet Age-Related Macular Degeneration in Japan: A Systematic Review and Pooled Data Analysis.

Authors:  Kanji Takahashi; Tomohiro Iida; Susumu Ishida; Bruce Crawford; Yoko Sakai; Akikazu Mochizuki; Ryuta Tsujiuchi; Satoru Tanaka; Kota Imai
Journal:  Clin Ophthalmol       Date:  2022-02-25

Review 5.  The roles of sex and gender in women's eye health disparities in the United States.

Authors:  Irene O Aninye; Kathleen Digre; M Elizabeth Hartnett; Kira Baldonado; Erin M Shriver; Laura M Periman; Julie Grutzmacher; Janine A Clayton
Journal:  Biol Sex Differ       Date:  2021-10-20       Impact factor: 8.811

Review 6.  Lutein and Zeaxanthin and Their Roles in Age-Related Macular Degeneration-Neurodegenerative Disease.

Authors:  Małgorzata Mrowicka; Jerzy Mrowicki; Ewa Kucharska; Ireneusz Majsterek
Journal:  Nutrients       Date:  2022-02-16       Impact factor: 5.717

7.  Novel Possible Protein Targets in Neovascular Age-Related Macular Degeneration: A Pilot Study Experiment.

Authors:  Bruno Nobre Lins Coronado; Felipe Bruno Santos da Cunha; Raphaela Menezes de Oliveira; Otávio de Toledo Nóbrega; Carlos André Ornelas Ricart; Wagner Fontes; Marcelo Valle de Sousa; Marcos Pereira de Ávila; Aline Maria Araújo Martins
Journal:  Front Med (Lausanne)       Date:  2022-01-27

8.  Efficacy and safety of brolucizumab versus aflibercept in patients with neovascular age-related macular degeneration: a randomized trial in Indian patients.

Authors:  Sanjay Kumar Mishra; Pradeep Kumar; Srishti Khullar; Amrita Joshi; Alok Sati; Sonali Vinay Kumar; Deepesh Unni; Atul Kumar
Journal:  Int J Retina Vitreous       Date:  2022-07-28

Review 9.  The Medicinal Chemistry of Artificial Nucleic Acids and Therapeutic Oligonucleotides.

Authors:  Miklós Bege; Anikó Borbás
Journal:  Pharmaceuticals (Basel)       Date:  2022-07-22

Review 10.  Galectins in the Pathogenesis of Common Retinal Disease.

Authors:  Bruna Caridi; Dilyana Doncheva; Sobha Sivaprasad; Patric Turowski
Journal:  Front Pharmacol       Date:  2021-05-17       Impact factor: 5.810
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