Fiona Pigny1, Noémie Wagner2, Marie Rohr2, Aline Mamin1, Pascal Cherpillod1, Klara M Posfay-Barbe2, Laurent Kaiser3, Isabella Eckerle4, Arnaud G L'Huillier5,6. 1. Laboratory of Virology, Geneva University Hospitals and Faculty of Medicine, 1211, Geneva, Switzerland. 2. Pediatric Infectious Diseases Unit, Geneva University Hospitals and Faculty of Medicine, 1211, Geneva, Switzerland. 3. Laboratory of Virology, Centre for Emerging Viral Diseases & Division of Infectious Diseases, Geneva University Hospitals and Faculty of Medicine, 1211, Geneva, Switzerland. 4. Laboratory of Virology & Centre for Emerging Viral Diseases, Geneva University Hospitals and Faculty of Medicine, 1211, Geneva, Switzerland. 5. Laboratory of Virology, Geneva University Hospitals and Faculty of Medicine, 1211, Geneva, Switzerland. Arnaud.Lhuillier@hcuge.ch. 6. Pediatric Infectious Diseases Unit, Geneva University Hospitals and Faculty of Medicine, 1211, Geneva, Switzerland. Arnaud.Lhuillier@hcuge.ch.
Abstract
We evaluated the rates of viral respiratory co-infections among SARS-CoV-2-infected children. Twelve percent of SARS-CoV-2-infected children had viral co-infection with one or more common respiratory viruses. This was significantly more frequent than among their SARS-CoV-2-infected adult household contacts (0%; p=0.028). Compared to the same period the previous year, common respiratory viruses were less frequently detected (12% vs 73%, p<0.001). Conclusion: Despite partial lockdown with school and daycare closure, and consequently similar exposure to common viruses between children and adults, SARS-CoV-2-infected children had more frequent viral respiratory co-infections than their SARS-CoV-2-infected adult household contacts. Circulation of common respiratory viruses was less frequent during the SARS-CoV-2 outbreak when compared to the same period last year, showing the impact of partial lockdown on the circulation of common viruses. What is Known: • Viral respiratory co-infections are frequent in children. • SARS-CoV-2 can be identified alongside other respiratory viruses, but data comparing children and adults are lacking. What is New: • Children infected with SARS-CoV-2 are more likely to have viral respiratory co-infections than their SARS-CoV-2-infected adult household contacts, which is surprising in the context of partial lockdown with schools and daycare closed. • When compared to data collected during the same period last year, our study also showed that partial lockdown reduced circulation of common respiratory viruses.
We evaluated the rates of viral respiratory co-infections among SARS-CoV-2-infectedchildren. Twelve percent of SARS-CoV-2-infectedchildren had viral co-infection with one or more common respiratory viruses. This was significantly more frequent than among their SARS-CoV-2-infected adult household contacts (0%; p=0.028). Compared to the same period the previous year, common respiratory viruses were less frequently detected (12% vs 73%, p<0.001). Conclusion: Despite partial lockdown with school and daycare closure, and consequently similar exposure to common viruses between children and adults, SARS-CoV-2-infectedchildren had more frequent viral respiratory co-infections than their SARS-CoV-2-infected adult household contacts. Circulation of common respiratory viruses was less frequent during the SARS-CoV-2 outbreak when compared to the same period last year, showing the impact of partial lockdown on the circulation of common viruses. What is Known: • Viral respiratory co-infections are frequent in children. • SARS-CoV-2 can be identified alongside other respiratory viruses, but data comparing children and adults are lacking. What is New: • Childreninfected with SARS-CoV-2 are more likely to have viral respiratory co-infections than their SARS-CoV-2-infected adult household contacts, which is surprising in the context of partial lockdown with schools and daycare closed. • When compared to data collected during the same period last year, our study also showed that partial lockdown reduced circulation of common respiratory viruses.
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