Ehsan Alimohammadi1, Arash Nikzad2, Mohammad Khedri3, Milad Rezaian4, Ahmad Miri Jahromi5, Nima Rezaei6,7,8, Reza Maleki9. 1. Neurosurgery Department, Kermanshah University of Medical Sciences, Kermanshah, Iran. 2. Department of Mechanical Engineering, University of British Columbia, 2054-6250 Applied Science Lane, Vancouver, BC V6T1Z4, Canada. 3. Department of Chemical Engineering, Amirkabir University of Technology (Tehran Polytechnic), 424 Hafez Avenue, Tehran 1591634311, Iran. 4. School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 19839 63113, Iran. 5. Department of Petroleum Engineering, Amirkabir University of Technology (Tehran Polytechnic), 424 Hafez Avenue, Tehran 1591634311, Iran. 6. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. 7. Network of Immunity in Infection, Malignancy & Autoimmunity (NIIMA), Universal Scientific Education & Research Network (USERN), Tehran, Iran. 8. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 9. Computational Biology & Chemistry Group (CBCG), Universal Scientific Education & Research Network (USERN), Tehran, Iran.
Abstract
Background: One of the underlying mechanisms of Parkinson's disease is the aggregation of α-synuclein proteins, including amyloids and Lewy bodies in the brain. Aim: To study the inhibitory effect of doped carbon nanotubes (CNTs) on amyloid aggregation. Materials & methods: Molecular dynamics tools were utilized to simulate the influence of CNTs doped with phosphorus, nitrogen and bromine and nitrogen on the formation of α-synuclein amyloid. Results: The CNTs exhibited strong interactions with α-synuclein, with phosphorus-doped CNTs having the most substantial interactions. Conclusion: Doped-CNTs, especially phosphorus-doped carbon nanotube could effectively prevent α-synuclein amyloid formation, thus, it could be considered as a potential treatment for Parkinson's disease. However, further in vitro and clinical investigations are required.
Background: One of the underlying mechanisms of Parkinson's disease is the aggregation of α-synuclein proteins, including amyloids and Lewy bodies in the brain. Aim: To study the inhibitory effect of doped carbon nanotubes (CNTs) on amyloid aggregation. Materials & methods: Molecular dynamics tools were utilized to simulate the influence of CNTs doped with phosphorus, nitrogen and bromine and nitrogen on the formation of α-synuclein amyloid. Results: The CNTs exhibited strong interactions with α-synuclein, with phosphorus-doped CNTs having the most substantial interactions. Conclusion: Doped-CNTs, especially phosphorus-doped carbon nanotube could effectively prevent α-synuclein amyloid formation, thus, it could be considered as a potential treatment for Parkinson's disease. However, further in vitro and clinical investigations are required.
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