Literature DB >> 33501569

Population-based, three-dimensional analysis of age- and sex-related femur shaft geometry differences.

I J Jung1, E J Choi2, B G Lee3, J W Kim4,5.   

Abstract

This study deals with differences of femoral geometric focus on the bowing and width. Analysis using three-dimensional skeletonization showed increase of femoral bowing and femur width over life (more in women), and widening of the medullary canal only in women after 50 years old, not in men.
INTRODUCTION: The changes in femur geometry that occur with aging and lead to fragility or insufficiency fracture remain unclear. The role of the lower limb geometry, including the femur and femoral bowing, has become a point of discussion, especially in atypical femur fracture. This study aimed to analyze femur shaft geometry using three-dimensional skeletonization.
METHODS: We acquired computed tomography images of both femurs obtained. A total of 1400 age- and sex-stratified participants were enrolled and were divided into subgroups according to age (by decade) and sex. The computed tomography images were used to produce 3-dimensional samplings of anatomical elements of the human femur using reconstruction and parametrization from these datasets. The process of skeletonization was conducted to obtain compact representation of the femur. With the skeletonization, we were able to compare all parameters according to age and sex.
RESULTS: The femur length was 424.4 ± 28.6 mm and was longer in men (P < 0.001). The minimum diameter of the medullary canal was 8.9 ± 2.0 mm. The radius of curvature (ROC) was 906.9 ± 193.3 mm. Men had a larger femur length, femur outer diameter, and the narrowest medullary diameter (P < 0.001, respectively). Women had significantly smaller ROC (P < 0.001). ROC decreased by 19.4% in men and 23.6% in women between the ages of 20 to 89 years. Femur width increased over life by 11.4% in men and 24.5% in women. Between the ages of 50 and 89 years, the medullary canal appears to have increased by 32.7% in women.
CONCLUSION: This geometry analysis demonstrated that femoral bowing and femoral width increased related to aging, and that the medullary canal widened after the age of 50 years in women. This cross-sectional study revealed important age- and sex-related differences in femur shaft geometry that occur with aging.

Entities:  

Keywords:  Aging; Femur; Femur bowing; Geometry; Three-dimensional analysis

Year:  2021        PMID: 33501569     DOI: 10.1007/s00198-021-05841-6

Source DB:  PubMed          Journal:  Osteoporos Int        ISSN: 0937-941X            Impact factor:   4.507


  22 in total

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2.  Mismatch of current intramedullary nails with the anterior bow of the femur.

Authors:  Kenneth A Egol; Eric Y Chang; John Cvitkovic; Frederick J Kummer; Kenneth J Koval
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3.  Variation in the femoral bow: a novel high-throughput analysis of 3922 femurs on cross-sectional imaging.

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Authors:  Ashutosh Chaturvedi; Zhenghong Lee
Journal:  Phys Med Biol       Date:  2005-03-16       Impact factor: 3.609

Review 5.  The Aging Skeleton.

Authors:  David Goltzman
Journal:  Adv Exp Med Biol       Date:  2019       Impact factor: 2.622

6.  Surgical tips of intramedullary nailing in severely bowed femurs in atypical femur fractures: Simulation with 3D printed model.

Authors:  Jai Hyung Park; Yongkoo Lee; Oog-Jin Shon; Hyun Chul Shon; Ji Wan Kim
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Review 7.  Atypical subtrochanteric and diaphyseal femoral fractures: second report of a task force of the American Society for Bone and Mineral Research.

Authors:  Elizabeth Shane; David Burr; Bo Abrahamsen; Robert A Adler; Thomas D Brown; Angela M Cheung; Felicia Cosman; Jeffrey R Curtis; Richard Dell; David W Dempster; Peter R Ebeling; Thomas A Einhorn; Harry K Genant; Piet Geusens; Klaus Klaushofer; Joseph M Lane; Fergus McKiernan; Ross McKinney; Alvin Ng; Jeri Nieves; Regis O'Keefe; Socrates Papapoulos; Tet Sen Howe; Marjolein C H van der Meulen; Robert S Weinstein; Michael P Whyte
Journal:  J Bone Miner Res       Date:  2013-10-01       Impact factor: 6.741

8.  Changes in bone mineral density of the proximal femur and spine with aging. Differences between the postmenopausal and senile osteoporosis syndromes.

Authors:  B L Riggs; H W Wahner; E Seeman; K P Offord; W L Dunn; R B Mazess; K A Johnson; L J Melton
Journal:  J Clin Invest       Date:  1982-10       Impact factor: 14.808

9.  Femoral shaft bowing with age: a digital radiological study of Anatolian Caucasian adults.

Authors:  Hakki Muammer Karakaş; Ahmet Harma
Journal:  Diagn Interv Radiol       Date:  2008-03       Impact factor: 2.630

10.  Femoral antecurvation-A 3D CT Analysis of 1232 adult femurs.

Authors:  Darius M Thiesen; Felix Prange; Josephine Berger-Groch; Dimitris Ntalos; Andreas Petersik; Bernhard Hofstätter; Johannes M Rueger; Till O Klatte; Maximilian J Hartel
Journal:  PLoS One       Date:  2018-10-09       Impact factor: 3.240

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  1 in total

1.  Differences in femur geometry and bone markers in atypical femur fractures and the general population.

Authors:  Ik Jae Jung; Ji Wan Kim
Journal:  Sci Rep       Date:  2021-12-17       Impact factor: 4.379

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