Literature DB >> 33501389

The neurological manifestations of COVID-19 - A case series.

Pranav V Karambelkar1, Chaitanya S Rojulpote1, Faryal Saeed1, Christina Pichiarello2, Nikul Patel2, Amit Sharma2.   

Abstract

Severe acute respiratory syndrome (SARS) is a fatal respiratory illness caused by the coronavirus (CoV). The first known case was reported in 2002, later coined as SARS-CoV. Over the last two decades, the CoV has periodically emerged in the general population, causing a varying degree of pneumonia. The most recent outbreak, now known as coronavirus disease of 2019 (COVID-19), has been on an exponential rise. Similar to its predecessors, COVID-19 causes a fatal form of pneumonia; however, in a small percentage of patients, COVID-19 has shown to cause neurological symptoms. Given that SARS-CoV and the new CoV strain share similar viral structures, COVID-19 may have the capability to invade the neurological system. We present a series of patients with COVID-19, the first of which presented with a seizure, whereas our second patient developed seizures during their hospital course. Neither patient had a previous history of epilepsy. RELEVANCE FOR PATIENTS: COVID-19 has rapidly evolved since it was first reported and has proven to be a fatal infective process. The last several months have been challenging for the medical community as we try to understand the complexities of this virus. Clinicians have attempted to assess the most common presenting symptoms based on reported cases. The purpose of this study was to help understand how COVID-19 presents itself when the neurological system is involved. This case series describes the common and uncommon neurological manifestations of COVID-19. By doing so, we hope to provide clinicians with additional information to help diagnose COVID-19 in this unprecedented time and to also be wary of the uncommon presenting features. Copyright: © Whioce Publishing Pte. Ltd.

Entities:  

Keywords:  COVID-19; SARS-CoV; neurological invasion; seizures

Year:  2020        PMID: 33501389      PMCID: PMC7821746     

Source DB:  PubMed          Journal:  J Clin Transl Res        ISSN: 2382-6533


  15 in total

1.  Neuroinvasion by human respiratory coronaviruses.

Authors:  N Arbour; R Day; J Newcombe; P J Talbot
Journal:  J Virol       Date:  2000-10       Impact factor: 5.103

Review 2.  Taste and smell GPCRs in the lung: Evidence for a previously unrecognized widespread chemosensory system.

Authors:  Steven S An; Stephen B Liggett
Journal:  Cell Signal       Date:  2017-02-04       Impact factor: 4.315

Review 3.  SARS-CoV and emergent coronaviruses: viral determinants of interspecies transmission.

Authors:  Meagan Bolles; Eric Donaldson; Ralph Baric
Journal:  Curr Opin Virol       Date:  2011-12       Impact factor: 7.090

4.  Multiple organ infection and the pathogenesis of SARS.

Authors:  Jiang Gu; Encong Gong; Bo Zhang; Jie Zheng; Zifen Gao; Yanfeng Zhong; Wanzhong Zou; Jun Zhan; Shenglan Wang; Zhigang Xie; Hui Zhuang; Bingquan Wu; Haohao Zhong; Hongquan Shao; Weigang Fang; Dongshia Gao; Fei Pei; Xingwang Li; Zhongpin He; Danzhen Xu; Xeying Shi; Virginia M Anderson; Anthony S-Y Leong
Journal:  J Exp Med       Date:  2005-07-25       Impact factor: 14.307

5.  Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains.

Authors:  Yuan Yuan; Duanfang Cao; Yanfang Zhang; Jun Ma; Jianxun Qi; Qihui Wang; Guangwen Lu; Ying Wu; Jinghua Yan; Yi Shi; Xinzheng Zhang; George F Gao
Journal:  Nat Commun       Date:  2017-04-10       Impact factor: 14.919

6.  Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.

Authors:  Chaolin Huang; Yeming Wang; Xingwang Li; Lili Ren; Jianping Zhao; Yi Hu; Li Zhang; Guohui Fan; Jiuyang Xu; Xiaoying Gu; Zhenshun Cheng; Ting Yu; Jiaan Xia; Yuan Wei; Wenjuan Wu; Xuelei Xie; Wen Yin; Hui Li; Min Liu; Yan Xiao; Hong Gao; Li Guo; Jungang Xie; Guangfa Wang; Rongmeng Jiang; Zhancheng Gao; Qi Jin; Jianwei Wang; Bin Cao
Journal:  Lancet       Date:  2020-01-24       Impact factor: 79.321

7.  A first case of meningitis/encephalitis associated with SARS-Coronavirus-2.

Authors:  Takeshi Moriguchi; Norikazu Harii; Junko Goto; Daiki Harada; Hisanori Sugawara; Junichi Takamino; Masateru Ueno; Hiroki Sakata; Kengo Kondo; Natsuhiko Myose; Atsuhito Nakao; Masayuki Takeda; Hirotaka Haro; Osamu Inoue; Katsue Suzuki-Inoue; Kayo Kubokawa; Shinji Ogihara; Tomoyuki Sasaki; Hiroyuki Kinouchi; Hiroyuki Kojin; Masami Ito; Hiroshi Onishi; Tatsuya Shimizu; Yu Sasaki; Nobuyuki Enomoto; Hiroshi Ishihara; Shiomi Furuya; Tomoko Yamamoto; Shinji Shimada
Journal:  Int J Infect Dis       Date:  2020-04-03       Impact factor: 3.623

Review 8.  The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients.

Authors:  Yan-Chao Li; Wan-Zhu Bai; Tsutomu Hashikawa
Journal:  J Med Virol       Date:  2020-03-11       Impact factor: 2.327

9.  Seizures as a rare adverse effect of chloroquine therapy in systemic lupus erythematosus patients: a case report and literature survey.

Authors:  Piotr Krzeminski; Aleksandra Lesiak; Joanna Narbutt
Journal:  Postepy Dermatol Alergol       Date:  2018-08-21       Impact factor: 1.837

10.  Clinical manifestations and evidence of neurological involvement in 2019 novel coronavirus SARS-CoV-2: a systematic review and meta-analysis.

Authors:  Lei Wang; Yin Shen; Man Li; Haoyu Chuang; Youfan Ye; Hongyang Zhao; Haijun Wang
Journal:  J Neurol       Date:  2020-06-11       Impact factor: 4.849

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.