Literature DB >> 3350132

Enhanced reactivity towards flunarizine in cerebrovascular bed of spontaneously hypertensive rats.

E Koźniewska1.   

Abstract

Cerebral blood flow (CBF) was measured and cerebrovascular resistance (CVR) was calculated in anesthetized spontaneously hypertensive rats (SHR) and normotensive rats (NR) following the administration of incremental dosages of i.v. flunarizine or papaverine. CBF and CVR changes following papaverine were the same in both groups of rats irrespective of the dose of the drug. The effect of flunarizine was much more pronounced in SHR than in NR. The results point out the greater dependency of basal cerebrovascular tone in SHR upon Ca2+ influx into vascular smooth muscle cells.

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Year:  1988        PMID： 3350132     DOI： 10.1007/bf01941712

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  14 in total

Review 1.  Mechanisms of vasodilatation and antivasoconstriction.

Authors:  J M Van Nueten; D Wellens
Journal:  Angiology       Date:  1979-07       Impact factor: 3.619

Review 2.  Calcium channel modulation by neurotransmitters, enzymes and drugs.

Authors:  H Reuter
Journal:  Nature       Date:  1983 Feb 17-23       Impact factor: 49.962

Review 3.  Physiological aspects of primary hypertension.

Authors:  B Folkow
Journal:  Physiol Rev       Date:  1982-04       Impact factor: 37.312

Review 4.  Cell membrane alteration as a source of primary hypertension.

Authors:  Y V Postnov; S N Orlov
Journal:  J Hypertens       Date:  1984-02       Impact factor: 4.844

5.  Rapid and repetitive measurements of blood flow and oxygen consumption in the rat brain using intraarterial xenon injection.

Authors:  M M Hertz; R Hemmingsen; T G Bolwig
Journal:  Acta Physiol Scand       Date:  1977-12

6.  Direct inhibitory effects of some 'calcium-antagonists' and trifluoperazine on the contractile proteins in smooth muscle.

Authors:  M Spedding
Journal:  Br J Pharmacol       Date:  1983-05       Impact factor: 8.739

7.  The vascular effects of flunarizine as compared with those of other clinically used vasoactive substances.

Authors:  J M Van Nueten; J Van Beek; P A Janssen
Journal:  Arzneimittelforschung       Date:  1978

8.  A comparison of the inhibitory effect of cinnarizine and papaverine on the noradrenaline- and calcium-evoked contraction of isolated rabbit aorta and mesenteric arteries.

Authors:  A Broekaert; T Godfraind
Journal:  Eur J Pharmacol       Date:  1979-01-15       Impact factor: 4.432

9.  Calcium leakage as a cause of the high resting tension in vascular smooth muscle from the spontaneously hypertensive rat.

Authors:  J P Noon; P J Rice; R J Baldessarini
Journal:  Proc Natl Acad Sci U S A       Date:  1978-03       Impact factor: 11.205

10.  Cerebral vasomotor reactivity in normotensive and spontaneously hypertensive rats.

Authors:  B B Johansson; B Nilsson
Journal:  Stroke       Date:  1979 Sep-Oct       Impact factor: 7.914
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