| Literature DB >> 33500101 |
Huibin Lv1, Nicholas C Wu2, Owen Tak-Yin Tsang3, Meng Yuan2, Ranawaka A P M Perera4, Wai Shing Leung3, Ray T Y So1, Jacky Man Chun Chan3, Garrick K Yip1, Thomas Shiu Hong Chik3, Yiquan Wang1, Chris Yau Chung Choi3, Yihan Lin1, Wilson W Ng1, Jincun Zhao5, Leo L M Poon1, J S Malik Peiris6, Ian A Wilson7, Chris K P Mok8.
Abstract
The World Health Organization has declared the ongoing outbreak of COVID-19, which is caused by a novel coronavirus SARS-CoV-2, a pandemic. There is currently a lack of knowledge about the antibody response elicited from SARS-CoV-2 infection. One major immunological question concerns antigenic differences between SARS-CoV-2 and SARS-CoV. We address this question by analyzing plasma from patients infected by SARS-CoV-2 or SARS-CoV and from infected or immunized mice. Our results show that, although cross-reactivity in antibody binding to the spike protein is common, cross-neutralization of the live viruses may be rare, indicating the presence of a non-neutralizing antibody response to conserved epitopes in the spike. Whether such low or non-neutralizing antibody response leads to antibody-dependent disease enhancement needs to be addressed in the future. Overall, this study not only addresses a fundamental question regarding antigenicity differences between SARS-CoV-2 and SARS-CoV but also has implications for immunogen design and vaccine development.Entities:
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Year: 2020 PMID： 33500101 DOI： 10.1016/j.celrep.2020.107725
Source DB: PubMed Journal: Cell Rep Impact factor: 9.423