Timotius Ivan Hariyanto1, Cynthia Putri2, Pricilla Frinka3, Jessica Louisa4, Nata Pratama Hardjo Lugito5, Andree Kurniawan6. 1. Universitas Pelita Harapan Fakultas Kedokteran, 146921, Faculty of Medicine, Tangerang, Banten, Indonesia; timotius.hariyanto95@gmail.com. 2. Universitas Pelita Harapan Fakultas Kedokteran, 146921, Faculty of Medicine, Tangerang, Banten, Indonesia; cynthiagunawan96@yahoo.com. 3. Universitas Pelita Harapan Fakultas Kedokteran, 146921, Faculty of Medicine, Tangerang, Banten, Indonesia; frinkapricilla@gmail.com. 4. Universitas Pelita Harapan Fakultas Kedokteran, 146921, Faculty of Medicine, Tangerang, Banten, Indonesia; Jessicalouisaa95@yahoo.com. 5. Universitas Pelita Harapan Fakultas Kedokteran, 146921, Department of Internal Medicine, Tangerang, Banten, Indonesia; nata.lugito@uph.edu. 6. Universitas Pelita Harapan Fakultas Kedokteran, 146921, Department of Internal Medicine, Boulevard Jendral Sudirman street, Karawaci, Tangerang, Tangerang, Banten, Indonesia, 15811; andree.kurniawan@uph.edu.
Abstract
AIDS Research and Human Retroviruses officially retracts the Instant Online/Just Accepted version of the article entitled, "Human Immunodeficiency Virus (HIV) and Outcomes from Coronavirus Disease 2019 (COVID-19) Pneumonia: A Meta-Analysis and Meta-Regression" (epub 27 Jan 2021; doi.org/10.1089/AID.2020.0307). A technical issue caused the accepted version to post online before all plagiarism checks were finalized. Those checks determined that there was too much duplication from previously published sources which prevented the continuance to final publication. The technical issue that caused the premature posting has since been corrected. AIDS Research and Human Retroviruses and its Publisher are committed to upholding the standards of scientific publishing and the community it serves. BACKGROUND: The number of positive and death cases from coronavirus disease 2019 (COVID-19) is still increasing until now. One of the most prone individuals, even in normal situations is patients with HIV. Currently, the evidence regarding the link between HIV and COVID-19 is still limited and conflicting. This study aims to analyze the relationship between HIV and poor outcomes of COVID-19 infection. METHODS: We systematically searched the PubMed and Europe PMC database using specific keywords related to our aims until January 12th, 2021. All articles published on COVID-19 and HIV were retrieved. The quality of the study was assessed using the Newcastle Ottawa Scale (NOS) tool for observational studies. Statistical analysis was done using Review Manager 5.4 and Comprehensive Meta-Analysis version 3 software. RESULTS: A total of 38 studies with 18,271,025 COVID-19 patients were included in this meta-analysis. This meta-analysis showed that HIV was not associated with composite poor outcome [OR 1.08 (95% CI 0.95 - 1.23), p = 0.26, I2 = 68%, random-effect modelling]. Meta-regression showed that the association with composite poor outcome was influenced by hypertension (p < 0.00001) and diabetes (p = 0.0007). Subgroup analysis which involves only studies from African region showed that HIV was associated with composite poor outcomes [OR 1.11 (95% CI 1.03 - 1.21), p = 0.01, I2 = 0%, random-effect modelling]. CONCLUSIONS: Patients with HIV should still be considered as a population for whom precautions are needed to prevent the COVID-19. The availability of antiretroviral therapy should be ensured.
AIDS Research and Human Retroviruses officially retracts the Instant Online/Just Accepted version of the article entitled, "Human Immunodeficiency Virus (HIV) and Outcomes from Coronavirus Disease2019 (COVID-19) Pneumonia: A Meta-Analysis and Meta-Regression" (epub 27 Jan 2021; doi.org/10.1089/AID.2020.0307). A technical issue caused the accepted version to post online before all plagiarism checks were finalized. Those checks determined that there was too much duplication from previously published sources which prevented the continuance to final publication. The technical issue that caused the premature posting has since been corrected. AIDS Research and Human Retroviruses and its Publisher are committed to upholding the standards of scientific publishing and the community it serves. BACKGROUND: The number of positive and death cases from coronavirus disease 2019 (COVID-19) is still increasing until now. One of the most prone individuals, even in normal situations is patients with HIV. Currently, the evidence regarding the link between HIV and COVID-19 is still limited and conflicting. This study aims to analyze the relationship between HIV and poor outcomes of COVID-19infection. METHODS: We systematically searched the PubMed and Europe PMC database using specific keywords related to our aims until January 12th, 2021. All articles published on COVID-19 and HIV were retrieved. The quality of the study was assessed using the Newcastle Ottawa Scale (NOS) tool for observational studies. Statistical analysis was done using Review Manager 5.4 and Comprehensive Meta-Analysis version 3 software. RESULTS: A total of 38 studies with 18,271,025 COVID-19patients were included in this meta-analysis. This meta-analysis showed that HIV was not associated with composite poor outcome [OR 1.08 (95% CI 0.95 - 1.23), p = 0.26, I2 = 68%, random-effect modelling]. Meta-regression showed that the association with composite poor outcome was influenced by hypertension (p < 0.00001) and diabetes (p = 0.0007). Subgroup analysis which involves only studies from African region showed that HIV was associated with composite poor outcomes [OR 1.11 (95% CI 1.03 - 1.21), p = 0.01, I2 = 0%, random-effect modelling]. CONCLUSIONS:Patients with HIV should still be considered as a population for whom precautions are needed to prevent the COVID-19. The availability of antiretroviral therapy should be ensured.
Authors: George A Yendewa; Jaime Abraham Perez; Kayla Schlick; Heather Tribout; Grace A McComsey Journal: Open Forum Infect Dis Date: 2021-06-01 Impact factor: 3.835