Literature DB >> 33499012

Nurse-Like Cells and Chronic Lymphocytic Leukemia B Cells: A Mutualistic Crosstalk inside Tissue Microenvironments.

Stefania Fiorcari1, Rossana Maffei1,2, Claudio Giacinto Atene1, Leonardo Potenza1,2, Mario Luppi1,2, Roberto Marasca1,2.   

Abstract

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in Western countries and is an example of hematological disease where cooperation between genetic defects and tumor microenvironmental interaction is involved in pathogenesis. CLL is a disease that is considered as "addicted to the host"; indeed, the crosstalk between leukemic cells and the tumor microenvironment is essential for leukemic clone maintenance supporting CLL cells' survival, proliferation, and protection from drug-induced apoptosis. CLL cells are not innocent bystanders but actively model and manipulate the surrounding microenvironment to their own advantage. Besides the different players involved in this crosstalk, nurse-like cells (NLC) resemble features related to leukemia-associated macrophages with an important function in preserving CLL cell survival and supporting an immunosuppressive microenvironment. This review provides a comprehensive overview of the role played by NLC in creating a nurturing and permissive milieu for CLL cells, illustrating the therapeutic possibilities in order to specifically target and re-educate them.

Entities:  

Keywords:  CLL; microenvironment; nurse-like cells

Year:  2021        PMID： 33499012      PMCID： PMC7911538          DOI： 10.3390/cells10020217

Source DB:  PubMed          Journal:  Cells        ISSN： 2073-4409            Impact factor:   6.600


  82 in total

1.  IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells.

Authors:  Maria Fernanda Pascutti; Margot Jak; Jacqueline M Tromp; Ingrid A M Derks; Ester B M Remmerswaal; Rachel Thijssen; Martijn H A van Attekum; Gregor G van Bochove; Dieuwertje M Luijks; Steven T Pals; René A W van Lier; Arnon P Kater; Marinus H J van Oers; Eric Eldering
Journal:  Blood       Date:  2013-09-06       Impact factor: 22.113

2.  Activation of NF-κB in B cell receptor signaling through Bruton's tyrosine kinase-dependent phosphorylation of IκB-α.

Authors:  Marilena Pontoriero; Giuseppe Fiume; Eleonora Vecchio; Annamaria de Laurentiis; Francesco Albano; Enrico Iaccino; Selena Mimmi; Antonio Pisano; Valter Agosti; Emilia Giovannone; Annalisa Altobelli; Carmen Caiazza; Massimo Mallardo; Giuseppe Scala; Ileana Quinto
Journal:  J Mol Med (Berl)       Date:  2019-03-19       Impact factor: 4.599

3.  Physical contact with endothelial cells through β1- and β2- integrins rescues chronic lymphocytic leukemia cells from spontaneous and drug-induced apoptosis and induces a peculiar gene expression profile in leukemic cells.

Authors:  Rossana Maffei; Stefania Fiorcari; Jenny Bulgarelli; Silvia Martinelli; Ilaria Castelli; Silvia Deaglio; Giulia Debbia; Marcella Fontana; Valeria Coluccio; Goretta Bonacorsi; Patrizia Zucchini; Franco Narni; Giuseppe Torelli; Mario Luppi; Roberto Marasca
Journal:  Haematologica       Date:  2011-12-29       Impact factor: 9.941

4.  Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro.

Authors:  P Panayiotidis; D Jones; K Ganeshaguru; L Foroni; A V Hoffbrand
Journal:  Br J Haematol       Date:  1996-01       Impact factor: 6.998

5.  Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells.

Authors:  L Lagneaux; A Delforge; D Bron; C De Bruyn; P Stryckmans
Journal:  Blood       Date:  1998-04-01       Impact factor: 22.113

6.  Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance.

Authors:  Antonina V Kurtova; Kumudha Balakrishnan; Rong Chen; Wei Ding; Susanne Schnabl; Maite P Quiroga; Mariela Sivina; William G Wierda; Zeev Estrov; Michael J Keating; Medhat Shehata; Ulrich Jäger; Varsha Gandhi; Neil E Kay; William Plunkett; Jan A Burger
Journal:  Blood       Date:  2009-09-17       Impact factor: 22.113

7.  T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production.

Authors:  John C Riches; Jeffrey K Davies; Fabienne McClanahan; Rewas Fatah; Sameena Iqbal; Samir Agrawal; Alan G Ramsay; John G Gribben
Journal:  Blood       Date:  2012-12-17       Impact factor: 22.113

8.  Ibrutinib blocks Btk-dependent NF-ĸB and NFAT responses in human macrophages during Aspergillus fumigatus phagocytosis.

Authors:  Amelia Bercusson; Thomas Colley; Anand Shah; Adilia Warris; Darius Armstrong-James
Journal:  Blood       Date:  2018-07-18       Impact factor: 25.476

9.  Co-culture of primary CLL cells with bone marrow mesenchymal cells, CD40 ligand and CpG ODN promotes proliferation of chemoresistant CLL cells phenotypically comparable to those proliferating in vivo.

Authors:  Noelia Purroy; Pau Abrisqueta; Júlia Carabia; Cecilia Carpio; Carles Palacio; Francesc Bosch; Marta Crespo
Journal:  Oncotarget       Date:  2015-04-10

10.  BDNF belongs to the nurse-like cell secretome and supports survival of B chronic lymphocytic leukemia cells.

Authors:  Thomas Naves; Anne-Laure Fauchais; Marie-Odile Jauberteau; Hugo Talbot; Sofiane Saada; Elodie Barthout; Paul-François Gallet; Nathalie Gachard; Julie Abraham; Arnaud Jaccard; Danielle Troutaud; Fabrice Lalloué
Journal:  Sci Rep       Date:  2020-07-28       Impact factor: 4.379
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  3 in total

1.  Elucidation of Focal Adhesion Kinase as a Modulator of Migration and Invasion and as a Potential Therapeutic Target in Chronic Lymphocytic Leukemia.

Authors:  Thomas A Burley; Andrew Hesketh; Giselda Bucca; Emma Kennedy; Eleni E Ladikou; Benjamin P Towler; Simon Mitchell; Colin P Smith; Christopher Fegan; Rosalynd Johnston; Andrea Pepper; Chris Pepper
Journal:  Cancers (Basel)       Date:  2022-03-22       Impact factor: 6.575

2.  Unravelling soluble immune checkpoints in chronic lymphocytic leukemia: Physiological immunomodulators or immune dysfunction.

Authors:  Alicia Landeira-Viñuela; Carlota Arias-Hidalgo; Pablo Juanes-Velasco; Miguel Alcoceba; Almudena Navarro-Bailón; Carlos Eduardo Pedreira; Quentin Lecrevisse; Laura Díaz-Muñoz; José Manuel Sánchez-Santos; Ángela-Patricia Hernández; Marina L García-Vaquero; Rafael Góngora; Javier De Las Rivas; Marcos González; Alberto Orfao; Manuel Fuentes
Journal:  Front Immunol       Date:  2022-09-28       Impact factor: 8.786

3.  BTK Inhibitors Impair Platelet-Mediated Antifungal Activity.

Authors:  Vincenzo Nasillo; Ivana Lagreca; Daniela Vallerini; Patrizia Barozzi; Giovanni Riva; Monica Maccaferri; Ambra Paolini; Fabio Forghieri; Stefania Fiorcari; Rossana Maffei; Silvia Martinelli; Claudio Giacinto Atene; Ilaria Castelli; Roberto Marasca; Leonardo Potenza; Patrizia Comoli; Rossella Manfredini; Enrico Tagliafico; Tommaso Trenti; Mario Luppi
Journal:  Cells       Date:  2022-03-16       Impact factor: 6.600
  3 in total

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