| Literature DB >> 33498870 |
Federica Piani1,2, Arrigo F G Cicero1,2, Claudio Borghi1,2.
Abstract
The relationship between serum uric acid (SUA) and hypertension has been a subject of increasing interest since the 1870 discovery by Frederick Akbar Mahomed. Several epidemiological studies have shown a strong association between high SUA levels and the presence or the development of hypertension. Genetic analyses have found that xanthine oxidoreductase (XOR) genetic polymorphisms are associated with hypertension. However, genetic studies on urate transporters and Mendelian randomization studies failed to demonstrate a causal relationship between SUA and hypertension. Results from clinical trials on the role of urate-lowering therapy in the management of patients with hypertension are not uniform. Our study sought to analyze the prognostic and therapeutic role of SUA in the hypertensive disease, from uric acid (UA) biology to clinical trials on urate-lowering therapies.Entities:
Keywords: cardiovascular risk; hypertension; urate-lowering therapy; uric acid; xanthine oxidase
Year: 2021 PMID： 33498870 PMCID： PMC7865830 DOI： 10.3390/jcm10030448
Source DB: PubMed Journal: J Clin Med ISSN： 2077-0383 Impact factor: 4.241