| Literature DB >> 33498803 |
Modibo Diarra1, Drissa Coulibaly1, Amadou Tapily1, Boureima Guindo1, Koualy Sanogo1, Diakalia Koné2, Youssouf Koné1, Karim Koné1, Aboudramane Bathily3, Oumar Yattara3, Mahamadou A Thera1, Alassane Dicko1, Abdoulaye A Djimdé1, Issaka Sagara1.
Abstract
In Mali, since 2007, artemether-lumefantrine has been the first choice against uncomplicated malaria. Despite its effectiveness, a rapid selection of markers of resistance to partner drugs has been documented. This work evaluated the treatment according to the World Health Organization's standard 28-day treatment method. The primary endpoint was the clinical and parasitological response corrected by a polymerase chain reaction. It was more than 99.9 percent, the proportion of patients with anemia significantly decrease compared to baseline (p < 0.001), and no serious events were recorded. Plasmodium falciparum remains sensitive to artemether-lumefantrine in Mali.Entities:
Keywords: Mali; Plasmodium falciparum; artemether-lumefantrine; in vivo efficacy; malaria
Year: 2021 PMID: 33498803 PMCID: PMC7838931 DOI: 10.3390/tropicalmed6010013
Source DB: PubMed Journal: Trop Med Infect Dis ISSN: 2414-6366