Literature DB >> 33498606

Design and Characterization of a Screw Extrusion Hot-End for Fused Deposition Modeling.

Tim Feuerbach1, Markus Thommes1.   

Abstract

The filament is the most widespread feedstock material form used for fused deposition modeling printers. Filaments must be manufactured with tight dimensional tolerances, both to be processable in the hot-end and to obtain printed objects of high quality. The ability to successfully feed the filament into the printer is also related to the mechanical properties of the filament, which are often insufficient for pharmaceutically relevant excipients. In the scope of this work, an 8 mm single screw hot-end was designed and characterized, which allows direct printing of materials from their powder form and does not require an intermediate filament. The capability of the hot-end to increase the range of applicable excipients to fused deposition modeling was demonstrated by processing and printing several excipients that are not suitable for fused deposition modeling in their filament forms, such as ethylene vinyl acetate and poly(1-vinylpyrrolidone-co-vinyl acetate). The conveying characteristic of the screw was investigated experimentally with all materials and was in agreement with an established model from literature. The complete design information, such as the screw geometry and the hot-end dimensions, is provided in this work.

Entities:  

Keywords:  3D printing; extrusion; filament; fused deposition modeling; hot-end; screw

Mesh:

Substances:

Year:  2021        PMID: 33498606      PMCID: PMC7865439          DOI: 10.3390/molecules26030590

Source DB:  PubMed          Journal:  Molecules        ISSN: 1420-3049            Impact factor:   4.411


  15 in total

Review 1.  Application of Fused Deposition Modelling (FDM) Method of 3D Printing in Drug Delivery.

Authors:  Jingjunjiao Long; Hamideh Gholizadeh; Jun Lu; Craig Bunt; Ali Seyfoddin
Journal:  Curr Pharm Des       Date:  2017       Impact factor: 3.116

2.  Characterisation of fused deposition modeling 3D printers for pharmaceutical and medical applications.

Authors:  Tim Feuerbach; Stefanie Kock; Markus Thommes
Journal:  Pharm Dev Technol       Date:  2018-07-23       Impact factor: 3.133

3.  Hot-melt extruded filaments based on pharmaceutical grade polymers for 3D printing by fused deposition modeling.

Authors:  Alice Melocchi; Federico Parietti; Alessandra Maroni; Anastasia Foppoli; Andrea Gazzaniga; Lucia Zema
Journal:  Int J Pharm       Date:  2016-05-20       Impact factor: 5.875

4.  Formulation development and process analysis of drug-loaded filaments manufactured via hot-melt extrusion for 3D-printing of medicines.

Authors:  Carolin Korte; Julian Quodbach
Journal:  Pharm Dev Technol       Date:  2018-02-09       Impact factor: 3.133

5.  Ethylene vinyl acetate (EVA) as a new drug carrier for 3D printed medical drug delivery devices.

Authors:  Natalja Genina; Jenny Holländer; Harri Jukarainen; Ermei Mäkilä; Jarno Salonen; Niklas Sandler
Journal:  Eur J Pharm Sci       Date:  2015-11-03       Impact factor: 4.384

6.  Filament Advance Detection Sensor for Fused Deposition Modelling 3D Printers.

Authors:  Enrique Soriano Heras; Fernando Blaya Haro; José M de Agustín Del Burgo; Manuel Islán Marcos; Roberto D'Amato
Journal:  Sensors (Basel)       Date:  2018-05-09       Impact factor: 3.576

7.  Development of a Simple Mechanical Screening Method for Predicting the Feedability of a Pharmaceutical FDM 3D Printing Filament.

Authors:  Jehad M Nasereddin; Nikolaus Wellner; Muqdad Alhijjaj; Peter Belton; Sheng Qi
Journal:  Pharm Res       Date:  2018-05-31       Impact factor: 4.200

Review 8.  Additive manufacturing of bone scaffolds.

Authors:  Youwen Yang; Guoyong Wang; Huixin Liang; Chengde Gao; Shuping Peng; Lida Shen; Cijun Shuai
Journal:  Int J Bioprint       Date:  2018-12-12

9.  Material Considerations for Fused-Filament Fabrication of Solid Dosage Forms.

Authors:  Evert Fuenmayor; Martin Forde; Andrew V Healy; Declan M Devine; John G Lyons; Christopher McConville; Ian Major
Journal:  Pharmaceutics       Date:  2018-04-02       Impact factor: 6.321

Review 10.  Advanced Pharmaceutical Applications of Hot-Melt Extrusion Coupled with Fused Deposition Modelling (FDM) 3D Printing for Personalised Drug Delivery.

Authors:  Deck Khong Tan; Mohammed Maniruzzaman; Ali Nokhodchi
Journal:  Pharmaceutics       Date:  2018-10-24       Impact factor: 6.321

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  1 in total

1.  Influence of Print Settings on the Critical Quality Attributes of Extrusion-Based 3D-Printed Caplets: A Quality-by-Design Approach.

Authors:  Silke Henry; Lotte De Wever; Valérie Vanhoorne; Thomas De Beer; Chris Vervaet
Journal:  Pharmaceutics       Date:  2021-12-03       Impact factor: 6.321

  1 in total

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