Nurul Aida Ngah1, Jithendra Ratnayake1,2, Paul R Cooper1, George J Dias3, Darryl C Tong1, Siti Noor Fazliah Mohd Noor4, Haizal Mohd Hussaini1. 1. Faculty of Dentistry, Sir John Walsh Research Institute, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand. 2. Department of Oral Sciences, Faculty of Dentistry, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand. 3. Department of Anatomy, School of Biomedical Sciences, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand. 4. Craniofacial and Biomaterial Sciences, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Bertam, Kepala Batas 13200, Malaysia.
Abstract
OBJECTIVE: The use of platelet concentrates (PCs) in oral and maxillofacial surgery, periodontology, and craniofacial surgery has been reported. While PCs provide a rich reservoir of autologous bioactive growth factors for tissue regeneration, their drawbacks include lack of utility for long-term application, low elastic modulus and strength, and limited storage capability. These issues restrict their broader application. This review focuses on the lyophilization of PCs (LPCs) and how this processing approach affects their biological and mechanical properties for application as a bioactive scaffold for craniofacial tissue regeneration. MATERIALS AND METHODS: A comprehensive search of five electronic databases, including Medline, PubMed, EMBASE, Web of Science, and Scopus, was conducted from 1946 until 2019 using a combination of search terms relating to this topic. RESULTS: Ten manuscripts were identified as being relevant. The use of LPCs was mostly studied in in vitro and in vivo craniofacial bone regeneration models. Notably, one clinical study reported the utility of LPCs for guided bone regeneration prior to dental implant placement. CONCLUSIONS: Lyophilization can enhance the inherent characteristics of PCs and extends shelf-life, enable their use in emergency surgery, and improve storage and transportation capabilities. In light of this, further preclinical studies and clinical trials are required, as LPCs offer a potential approach for clinical application in craniofacial tissue regeneration.
OBJECTIVE: The use of platelet concentrates (PCs) in oral and maxillofacial surgery, periodontology, and craniofacial surgery has been reported. While PCs provide a rich reservoir of autologous bioactive growth factors for tissue regeneration, their drawbacks include lack of utility for long-term application, low elastic modulus and strength, and limited storage capability. These issues restrict their broader application. This review focuses on the lyophilization of PCs (LPCs) and how this processing approach affects their biological and mechanical properties for application as a bioactive scaffold for craniofacial tissue regeneration. MATERIALS AND METHODS: A comprehensive search of five electronic databases, including Medline, PubMed, EMBASE, Web of Science, and Scopus, was conducted from 1946 until 2019 using a combination of search terms relating to this topic. RESULTS: Ten manuscripts were identified as being relevant. The use of LPCs was mostly studied in in vitro and in vivo craniofacial bone regeneration models. Notably, one clinical study reported the utility of LPCs for guided bone regeneration prior to dental implant placement. CONCLUSIONS: Lyophilization can enhance the inherent characteristics of PCs and extends shelf-life, enable their use in emergency surgery, and improve storage and transportation capabilities. In light of this, further preclinical studies and clinical trials are required, as LPCs offer a potential approach for clinical application in craniofacial tissue regeneration.
Authors: David M Dohan; Joseph Choukroun; Antoine Diss; Steve L Dohan; Anthony J J Dohan; Jaafar Mouhyi; Bruno Gogly Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Date: 2006-01-10
Authors: Joseph Choukroun; Antoine Diss; Alain Simonpieri; Marie-Odile Girard; Christian Schoeffler; Steve L Dohan; Anthony J J Dohan; Jaafar Mouhyi; David M Dohan Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Date: 2006-03
Authors: Burak Kutlu; Rahime Seda Tiğlı Aydın; Abdullah C Akman; Menemşe Gümüşderelioglu; Rahime M Nohutcu Journal: J Biomed Mater Res B Appl Biomater Date: 2012-09-15 Impact factor: 3.368
Authors: M S Read; R L Reddick; A P Bode; D A Bellinger; T C Nichols; K Taylor; S V Smith; D K McMahon; T R Griggs; K M Brinkhous Journal: Proc Natl Acad Sci U S A Date: 1995-01-17 Impact factor: 11.205
Authors: Qi Li; David A Reed; Liu Min; Gokul Gopinathan; Steve Li; Smit J Dangaria; Leo Li; Yajun Geng; Maria-Therese Galang; Praveen Gajendrareddy; Yanmin Zhou; Xianghong Luan; Thomas G H Diekwisch Journal: Int J Mol Sci Date: 2014-05-14 Impact factor: 5.923
Authors: Nurul Aida Ngah; George J Dias; Darryl C Tong; Siti Noor Fazliah Mohd Noor; Jithendra Ratnayake; Paul R Cooper; Haizal Mohd Hussaini Journal: Molecules Date: 2021-11-25 Impact factor: 4.411