Literature DB >> 33497819

Non-coding RNA crosstalk with nuclear receptors in liver disease.

Jianguo Wu1, Laura E Nagy2, Suthat Liangpunsakul3, Li Wang4.   

Abstract

The dysregulation of nuclear receptors (NRs) underlies the pathogenesis of a variety of liver disorders. Non-coding RNAs (ncRNAs) are defined as RNA molecules transcribed from DNA but not translated into proteins. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are two types of ncRNAs that have been extensively studied for regulating gene expression during diverse cellular processes. NRs as therapeutic targets in liver disease have been exemplified by the successful application of their pharmacological ligands in clinics. MiRNA-based reagents or drugs are emerging as flagship products in clinical trials. Advancing our understanding of the crosstalk between NRs and ncRNAs is critical to the development of diagnostic and therapeutic strategies. This review summarizes recent findings on the reciprocal regulation between NRs and ncRNAs (mainly on miRNAs and lncRNAs) and their implication in liver pathophysiology, which might be informative to the translational medicine of targeting NRs and ncRNAs in liver disease.
Copyright © 2021 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  ALD; Bile acids; Cholestatic liver disease; Drug-induced liver injury; Fibrosis; HCC; Hepatitis; Inflammation; Lipid metabolism; Liver cancer; NAFLD; NASH; Steatosis

Mesh：

Substances：

Year:  2021        PMID： 33497819      PMCID： PMC7987766          DOI： 10.1016/j.bbadis.2021.166083

Source DB:  PubMed          Journal:  Biochim Biophys Acta Mol Basis Dis        ISSN： 0925-4439            Impact factor:   5.187


  247 in total

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4.  Astemizole promotes the anti-tumor effect of vitamin D through inhibiting miR-125a-5p-meidated regulation of VDR in HCC.

Authors:  Junli Xu; Yan Wang; Ya Zhang; Shan Dang; Shuixiang He
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5.  FXR Inhibits Endoplasmic Reticulum Stress-Induced NLRP3 Inflammasome in Hepatocytes and Ameliorates Liver Injury.

Authors:  Chang Yeob Han; Hyun Soo Rho; Ayoung Kim; Tae Hyun Kim; Kiseok Jang; Dae Won Jun; Jong Won Kim; Bumseok Kim; Sang Geon Kim
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Journal:  Nature       Date:  2014-03-27       Impact factor: 49.962

7.  Human box C/D snoRNAs with miRNA like functions: expanding the range of regulatory RNAs.

Authors:  Markus Brameier; Astrid Herwig; Richard Reinhardt; Lutz Walter; Jens Gruber
Journal:  Nucleic Acids Res       Date:  2010-09-15       Impact factor: 16.971

8.  Augmenter of liver regeneration protein deficiency promotes hepatic steatosis by inducing oxidative stress and microRNA-540 expression.

Authors:  Sudhir Kumar; Richa Rani; Rebekah Karns; Chandrashekhar R Gandhi
Journal:  FASEB J       Date:  2018-12-12       Impact factor: 5.834

9.  A metabolic stress-inducible miR-34a-HNF4α pathway regulates lipid and lipoprotein metabolism.

Authors:  Yang Xu; Munaf Zalzala; Jiesi Xu; Yuanyuan Li; Liya Yin; Yanqiao Zhang
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10.  Long non-coding RNA SPRY4-IT1 promotes development of hepatic cellular carcinoma by interacting with ERRα and predicts poor prognosis.

Authors:  Guifang Yu; Jieheng Lin; Chengcheng Liu; Kailian Hou; Min Liang; Boyun Shi
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  3 in total

1.  Cholesterol Metabolism in Chronic Kidney Disease: Physiology, Pathologic Mechanisms, and Treatment.

Authors:  Xiaoyue Pan
Journal:  Adv Exp Med Biol       Date:  2022       Impact factor: 2.622

Review 2.  The long and the small collide: LncRNAs and small heterodimer partner (SHP) in liver disease.

Authors:  Jianguo Wu; Laura E Nagy; Li Wang
Journal:  Mol Cell Endocrinol       Date:  2021-03-26       Impact factor: 4.369

3.  MiR-200c-3p targets SESN1 and represses the IL-6/AKT loop to prevent cholangiocyte activation and cholestatic liver fibrosis.

Authors:  Yongfeng Song; Melanie Tran; Li Wang; Dong-Ju Shin; Jianguo Wu
Journal:  Lab Invest       Date:  2021-12-08       Impact factor: 5.502
  3 in total

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