Vita Jaspan1, Kevin Lin2, Violeta Popov3. 1. Department of Medicine, NYU Langone Health, 550 1st Ave, New York, NY, 10016, USA. Electronic address: vita.jaspan@nyulangone.org. 2. Department of Medicine, NYU Langone Health, 550 1st Ave, New York, NY, 10016, USA. Electronic address: kevin.lin@nyulangone.org. 3. Division of Gastroenterology, Department of Medicine, NYU Langone Health, VA New York Harbor Health Care System, New York, NY, 10010, USA. Electronic address: violeta.popov@nyulangone.org.
Abstract
BACKGROUND & AIMS: Our study aims to clarify the relationship between weight parameters and colorectal cancer outcomes. METHODS: NCBI, Embase, Cochrane, and Web of Science were searched from inception to December 2019. Studies reporting colorectal cancer (CRC) mortality, recurrence, disease-free survival, overall survival, overall mortality stratified by pre-diagnosis BMI or post-diagnosis weight change, were included in the analysis. Random effects analysis was performed for all outcomes, with heterogeneity assessed by the I2 statistic. RESULTS: Our meta-analysis included 45 studies encompassing 607,266 patients. Obesity was associated with increased odds of overall mortality and CRC-specific mortality compared to normal weight (p < 0.001). Patients with underweight BMI had increased odds of CRC-specific mortality compared to normal BMI but were not significantly different from obese BMI. CONCLUSIONS: Obese and underweight BMI are associated with increased CRC-specific and overall mortality compared to normal BMI. Long term prognosis was similar for patients with obese and underweight BMI.
BACKGROUND & AIMS: Our study aims to clarify the relationship between weight parameters and colorectal cancer outcomes. METHODS: NCBI, Embase, Cochrane, and Web of Science were searched from inception to December 2019. Studies reporting colorectal cancer (CRC) mortality, recurrence, disease-free survival, overall survival, overall mortality stratified by pre-diagnosis BMI or post-diagnosis weight change, were included in the analysis. Random effects analysis was performed for all outcomes, with heterogeneity assessed by the I2 statistic. RESULTS: Our meta-analysis included 45 studies encompassing 607,266 patients. Obesity was associated with increased odds of overall mortality and CRC-specific mortality compared to normal weight (p < 0.001). Patients with underweight BMI had increased odds of CRC-specific mortality compared to normal BMI but were not significantly different from obese BMI. CONCLUSIONS:Obese and underweight BMI are associated with increased CRC-specific and overall mortality compared to normal BMI. Long term prognosis was similar for patients with obese and underweight BMI.
Authors: Michael W Greene; Peter T Abraham; Peyton C Kuhlers; Elizabeth A Lipke; Martin J Heslin; Stanley T Wijaya; Ifeoluwa Odeniyi Journal: PLoS One Date: 2022-05-13 Impact factor: 3.752
Authors: Edward L Giovannucci; Xuehong Zhang; Stephanie A Smith-Warner; Rui Song; Joshua Petimar; Molin Wang; Fred K Tabung; Mingyang Song; Li Liu; Dong Hoon Lee Journal: Cancer Epidemiol Biomarkers Prev Date: 2021-07-16 Impact factor: 4.090