Lindsay J Rotblatt1, Adrienne T Aiken-Morgan2,3, Michael Marsiske1, Ann L Horgas4, Kelsey R Thomas5,6. 1. Department of Clinical and Health Psychology, 3463University of Florida, Gainesville, FL, USA. 2. 3616North Carolina Agricultural and Technical State University Greensboro, NC, USA. 3. Duke University, Durham, NC, USA. 4. Department of Biobehavioral Nursing Science, 3463University of Florida, Gainesville, FL, USA. 5. 19979Veterans Affairs San Diego Healthcare System, San Diego, CA, USA. 6. 12220University of California San Diego, La Jolla, CA, USA.
Abstract
Objectives: Given prevalence differences of mild cognitive impairment (MCI) among Black and white older adults, this study aimed to examine whether overall vascular risk factor (VRF) burden and individual VRF associations with amnestic (aMCI) and nonamnestic (naMCI) MCI status varied by Black/white race. Methods: Participants included 2755 older adults without dementia from the ACTIVE study. Comprehensive neuropsychological criteria were used to classify cognitively normal, aMCI, and naMCI. VRFs were primarily defined using subjective report and medication data. Multinomial logistic regression was run predicting MCI subtype. Results: Greater overall VRF burden, high cholesterol, and obesity evinced greater odds of naMCI in Black participants than whites. Across participants, diabetes and hypertension were associated with increased odds of aMCI and naMCI, respectively. Discussion: Results may reflect known systemic inequities on dimensions of social determinants of health for Black older adults. Continued efforts toward examining underlying mechanisms contributing to these findings are critical.
Objectives: Given prevalence differences of mild cognitive impairment (MCI) among Black and white older adults, this study aimed to examine whether overall vascular risk factor (VRF) burden and individual VRF associations with amnestic (aMCI) and nonamnestic (naMCI) MCI status varied by Black/white race. Methods: Participants included 2755 older adults without dementia from the ACTIVE study. Comprehensive neuropsychological criteria were used to classify cognitively normal, aMCI, and naMCI. VRFs were primarily defined using subjective report and medication data. Multinomial logistic regression was run predicting MCI subtype. Results: Greater overall VRF burden, high cholesterol, and obesity evinced greater odds of naMCI in Black participants than whites. Across participants, diabetes and hypertension were associated with increased odds of aMCI and naMCI, respectively. Discussion: Results may reflect known systemic inequities on dimensions of social determinants of health for Black older adults. Continued efforts toward examining underlying mechanisms contributing to these findings are critical.
Authors: Jennifer J Manly; Diane M Jacobs; Pegah Touradji; Scott A Small; Yaakov Stern Journal: J Int Neuropsychol Soc Date: 2002-03 Impact factor: 2.892
Authors: J B Jobe; D M Smith; K Ball; S L Tennstedt; M Marsiske; S L Willis; G W Rebok; J N Morris; K F Helmers; M D Leveck; K Kleinman Journal: Control Clin Trials Date: 2001-08
Authors: Eseosa T Ighodaro; Peter T Nelson; Walter A Kukull; Frederick A Schmitt; Erin L Abner; Allison Caban-Holt; Shoshana H Bardach; Derrick C Hord; Crystal M Glover; Gregory A Jicha; Linda J Van Eldik; Alexander X Byrd; Anita Fernander Journal: J Alzheimers Dis Date: 2017 Impact factor: 4.472
Authors: Adrienne T Aiken Morgan; Michael Marsiske; Joseph M Dzierzewski; Richard N Jones; Keith E Whitfield; Kathy E Johnson; Mary K Cresci Journal: Exp Aging Res Date: 2010-10 Impact factor: 1.645
Authors: Jennifer Weuve; Lisa L Barnes; Carlos F Mendes de Leon; Kumar B Rajan; Todd Beck; Neelum T Aggarwal; Liesi E Hebert; David A Bennett; Robert S Wilson; Denis A Evans Journal: Epidemiology Date: 2018-01 Impact factor: 4.822
Authors: Paul W H Brewster; Rebecca J Melrose; María J Marquine; Julene K Johnson; Anna Napoles; Anna MacKay-Brandt; Sarah Farias; Bruce Reed; Dan Mungas Journal: Neuropsychology Date: 2014-06-16 Impact factor: 3.295