| Literature DB >> 33496743 |
Nobuaki Nakano1,2, Atae Utsunomiya1,2, Keitaro Matsuo3,4, Noriaki Yoshida5,6, Masao Seto5, Kouichi Ohshima5, Hiroshi Fujiwara7, Shigeo Fuji8, Yoshifusa Takatsuka1,2, Ayumu Ito9, Toshihiro Miyamoto10, Youko Suehiro11, Hirohisa Nakamae12, Yasushi Sawayama13, Mitsuhiro Yuasa14, Yasuhiko Miyazaki15, Shuichi Ota16, Kazunori Imada17, Takahiro Fukuda9, Tatsuo Ichinohe18, Yoshiko Atsuta19,20, Koji Kato10.
Abstract
Adult T-cell leukemia/lymphoma (ATL) cells frequently exhibit chromosomal abnormalities, including numerical aberrations and structural defects. However, no studies have examined the correlation between these abnormalities and survival in patients with ATL after allogeneic HSCT (allo-HSCT). In this study, 300 patients with ATL (median age, 55 years; range, 24-74) who were registered in a Japanese nationwide registry database were analyzed. The majority (n = 183) had acute ATL. Specimens for chromosomal analysis were collected from bone marrow (n = 166), lymph nodes (n = 86), peripheral blood (n = 41), and other locations (n = 7). In survival analyses, breakpoints at 2q (hazard ratio [HR], 1.63; 95% confidence interval [CI], 1.12-2.38; P = .012) and 5q (HR, 2.18; 95% CI, 1.25-3.80; P = .006) were significantly poor prognostic factors for overall survival (OS). In terms of ATL-related death, loss of chromosome 14 and breakpoints at 3p, 1q, 5q, and 6q were extracted as significantly poor prognostic factors. Moreover, complex karyotypes were associated with ATL-related death. This study of the survival impact of chromosomal abnormalities in patients with ATL after allo-HSCT demonstrated that several structural breakpoints were independent risk factors for OS and ATL-related death.Entities:
Mesh：
Year: 2021 PMID： 33496743 PMCID： PMC7839361 DOI： 10.1182/bloodadvances.2020003639
Source DB: PubMed Journal: Blood Adv ISSN： 2473-9529