Zhi-Xin Huang1,2,3, Jin Fang4, Chang-Hua Zhou5, Jie Zeng6, Dong Yang7, Zhenguo Liu3. 1. Stroke Center & Department of Neurology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China. 2. Department of Neurology, the Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China. 3. Department of Medicine, Center for Precision Medicine & Division of Cardiovascular Medicine, University of Missouri School of Medicine, Columbia, MO 65212, USA. 4. Department of Radiology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China. 5. Department of Hematology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China. 6. Center for Clinical Epidemiology & Methodology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China. 7. Guangzhou AID Cloud Technology, Guangzhou, Guangdong, China.
Abstract
Background: Endothelial dysfunction is considered to be involved in the pathogenesis of cerebral small vessel disease (CSVD). Endothelial progenitor cells are associated with endothelial dysfunction. The present study was designed to investigate the correlation between the populations of circulating CD34-positive cells and endothelial progenitor cells and CSVD burden. Methodology & results: A total of 364 patients with confirmed diagnosis of CSVD were included in this prospective study. Multiple ordinal logistic regression analyses showed that subjects with higher CSVD burden had significantly decreased circulating CD34+ cell level (odds ratio [OR], 0.42; p = 0.034) and significantly increased levels of circulating CD34+CD133+CD309+ and CD34+CD133+ cells (OR 1.07, p = 0.031; OR 1.03, p = 0.001, respectively), compared with patients with lower CSVD burden. Conclusion: The findings suggest that the levels of circulating CD34+ cells, CD34+CD133+CD309+ cells and CD34+CD133+ cells may be used as potential biomarkers to monitor the disease progression of CSVD.
Background: Endothelial dysfunction is considered to be involved in the pathogenesis of cerebral small vessel disease (CSVD). Endothelial progenitor cells are associated with endothelial dysfunction. The present study was designed to investigate the correlation between the populations of circulating CD34-positive cells and endothelial progenitor cells and CSVD burden. Methodology & results: A total of 364 patients with confirmed diagnosis of CSVD were included in this prospective study. Multiple ordinal logistic regression analyses showed that subjects with higher CSVD burden had significantly decreased circulating CD34+ cell level (odds ratio [OR], 0.42; p = 0.034) and significantly increased levels of circulating CD34+CD133+CD309+ and CD34+CD133+ cells (OR 1.07, p = 0.031; OR 1.03, p = 0.001, respectively), compared with patients with lower CSVD burden. Conclusion: The findings suggest that the levels of circulating CD34+ cells, CD34+CD133+CD309+ cells and CD34+CD133+ cells may be used as potential biomarkers to monitor the disease progression of CSVD.
Authors: Paul Philipp Heinisch; Corina Bello; Maximilian Y Emmert; Thierry Carrel; Martina Dreßen; Jürgen Hörer; Bernhard Winkler; Markus M Luedi Journal: Cells Date: 2022-05-18 Impact factor: 7.666