Literature DB >> 33496164

Airway smooth muscle and airway hyperresponsiveness in asthma: mechanisms of airway smooth muscle dysfunction.

Eric B Gebski1, Omkar Anaspure1, Reynold A Panettieri1, Cynthia J Koziol-White2.   

Abstract

Airway smooth muscle plays a pivotal role in modulating bronchomotor tone. Modulation of contractile and relaxation signaling is critical to alleviate the airway hyperresponsiveness (AHR) associated with asthma. Emerging studies examining the phenotype of ASM in the context of asthma provide rich avenues to develop more effective therapeutics to attenuate the AHR associated with the disease.

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Mesh：

Year:  2021        PMID： 33496164      PMCID： PMC9254130          DOI： 10.23736/S0026-4806.21.07283-9

Source DB:  PubMed          Journal:  Minerva Med        ISSN： 0026-4806            Impact factor:   5.580


  104 in total

1.  Endogenous Gs-coupled receptors in smooth muscle exhibit differential susceptibility to GRK2/3-mediated desensitization.

Authors:  Kok Choi Kong; Uma Gandhi; T J Martin; Candace B Anz; Huandong Yan; Anna M Misior; Rodolfo M Pascual; Deepak A Deshpande; Raymond B Penn
Journal:  Biochemistry       Date:  2008-08-09       Impact factor: 3.162

2.  Role of the adapter protein Abi1 in actin-associated signaling and smooth muscle contraction.

Authors:  Tao Wang; Rachel A Cleary; Ruping Wang; Dale D Tang
Journal:  J Biol Chem       Date:  2013-06-05       Impact factor: 5.157

3.  Differential induction of CD38 expression by TNF-{alpha} in asthmatic airway smooth muscle cells.

Authors:  Joseph A Jude; Julian Solway; Reynold A Panettieri; Timothy F Walseth; Mathur S Kannan
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2010-08-06       Impact factor: 5.464

4.  Tumor necrosis factor-alpha-induced activation of RhoA in airway smooth muscle cells: role in the Ca2+ sensitization of myosin light chain20 phosphorylation.

Authors:  Irene Hunter; Hannah J Cobban; Peter Vandenabeele; David J MacEwan; Graeme F Nixon
Journal:  Mol Pharmacol       Date:  2003-03       Impact factor: 4.436

5.  RGS4 Overexpression in Lung Attenuates Airway Hyperresponsiveness in Mice.

Authors:  Laura A Madigan; Gordon S Wong; Elizabeth M Gordon; Wei-Sheng Chen; Nariman Balenga; Cynthia J Koziol-White; Reynold A Panettieri; Stewart J Levine; Kirk M Druey
Journal:  Am J Respir Cell Mol Biol       Date:  2018-01       Impact factor: 6.914

6.  A CREB-mediated increase in miRNA let-7f during prolonged β-agonist exposure: a novel mechanism of β2-adrenergic receptor down-regulation in airway smooth muscle.

Authors:  Donghwa Kim; Soomin Cho; Jung A Woo; Stephen B Liggett
Journal:  FASEB J       Date:  2018-02-13       Impact factor: 5.191

7.  A major functional role for phosphodiesterase 4D5 in human airway smooth muscle cells.

Authors:  Charlotte K Billington; Ivan R Le Jeune; Kenneth W Young; Ian P Hall
Journal:  Am J Respir Cell Mol Biol       Date:  2007-08-02       Impact factor: 6.914

8.  β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D.

Authors:  Thomas Trian; Janette K Burgess; Kyoko Niimi; Lyn M Moir; Qi Ge; Patrick Berger; Stephen B Liggett; Judith L Black; Brian G Oliver
Journal:  PLoS One       Date:  2011-05-17       Impact factor: 3.240

9.  Epac as a novel effector of airway smooth muscle relaxation.

Authors:  Sara S Roscioni; Harm Maarsingh; Carolina R S Elzinga; Janke Schuur; Mark Menzen; Andrew J Halayko; Herman Meurs; Martina Schmidt
Journal:  J Cell Mol Med       Date:  2011-07       Impact factor: 5.310

Review 10.  Critical role of actin-associated proteins in smooth muscle contraction, cell proliferation, airway hyperresponsiveness and airway remodeling.

Authors:  Dale D Tang
Journal:  Respir Res       Date:  2015-10-30
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