| Literature DB >> 33495439 |
Ditte Demontis1,2,3, Raymond K Walters4,5, Veera M Rajagopal6,7,8, Irwin D Waldman9, Jakob Grove6,7,8,10, Thomas D Als6,7,8, Søren Dalsgaard11, Marta Ribasés12,13,14,15, Jonas Bybjerg-Grauholm6,16, Maria Bækvad-Hansen6,16, Thomas Werge6,17,18,19, Merete Nordentoft6,20,21, Ole Mors6,22, Preben Bo Mortensen6,7,11,23, Bru Cormand15,24,25,26, David M Hougaard6,16, Benjamin M Neale4,5,27, Barbara Franke28,29, Stephen V Faraone30, Anders D Børglum31,32,33.
Abstract
Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder often comorbid with disruptive behavior disorders (DBDs). Here, we report a GWAS meta-analysis of ADHD comorbid with DBDs (ADHD + DBDs) including 3802 cases and 31,305 controls. We identify three genome-wide significant loci on chromosomes 1, 7, and 11. A meta-analysis including a Chinese cohort supports that the locus on chromosome 11 is a strong risk locus for ADHD + DBDs across European and Chinese ancestries (rs7118422, P = 3.15×10-10, OR = 1.17). We find a higher SNP heritability for ADHD + DBDs (h2SNP = 0.34) when compared to ADHD without DBDs (h2SNP = 0.20), high genetic correlations between ADHD + DBDs and aggressive (rg = 0.81) and anti-social behaviors (rg = 0.82), and an increased burden (polygenic score) of variants associated with ADHD and aggression in ADHD + DBDs compared to ADHD without DBDs. Our results suggest an increased load of common risk variants in ADHD + DBDs compared to ADHD without DBDs, which in part can be explained by variants associated with aggressive behavior.Entities:
Mesh：
Year: 2021 PMID： 33495439 PMCID： PMC7835232 DOI： 10.1038/s41467-020-20443-2
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919