Literature DB >> 33491763

Patient iPSC-derived retinal organoids: Observable retinal diseases in-a-dish.

Xiao-Hui Zhang1, Zi-Bing Jin2.   

Abstract

Induced pluripotent stem cells (iPSCs), reprogrammed from human somatic cells, hold the capacity to differentiate into most human body cells. iPSCs can be differentiated into retinal organoids, a three-dimensional structured retina containing various retinal cells. Patient-specific retinal organoids provide a powerful disease model to recapitulate the disease to study the pathogenesis of inherited retinal dystrophies, to screen or discover new drugs, and most importantly to supply an unlimited cell source for retinal regeneration.

Entities:  

Mesh：

Year:  2021        PMID： 33491763     DOI： 10.14670/HH-18-307

Source DB:  PubMed          Journal:  Histol Histopathol        ISSN： 0213-3911            Impact factor:   2.303


  38 in total

1.  Using CRISPR-Cas9 to Generate Gene-Corrected Autologous iPSCs for the Treatment of Inherited Retinal Degeneration.

Authors:  Erin R Burnight; Manav Gupta; Luke A Wiley; Kristin R Anfinson; Audrey Tran; Robinson Triboulet; Jeremy M Hoffmann; Darcey L Klaahsen; Jeaneen L Andorf; Chunhua Jiao; Elliott H Sohn; Malavika K Adur; Jason W Ross; Robert F Mullins; George Q Daley; Thorsten M Schlaeger; Edwin M Stone; Budd A Tucker
Journal:  Mol Ther       Date:  2017-06-12       Impact factor: 11.454

Review 2.  Stem cell-based retina models.

Authors:  Kevin Achberger; Jasmin C Haderspeck; Alexander Kleger; Stefan Liebau
Journal:  Adv Drug Deliv Rev       Date:  2018-05-17       Impact factor: 15.470

3.  Generation of gene-corrected human induced pluripotent stem cell lines derived from retinitis pigmentosa patient with Ser331Cysfs*5 mutation in MERTK.

Authors:  Ana Artero Castro; Kathleen Long; Andrew Bassett; Candela Machuca; Marian León; Almudena Ávila-Fernandez; Marta Cortón; Toni Vidal-Puig; Carmen Ayuso; Dunja Lukovic; Slaven Erceg
Journal:  Stem Cell Res       Date:  2018-11-16       Impact factor: 2.020

Review 4.  Retinoblastoma.

Authors:  Helen Dimaras; Kahaki Kimani; Elizabeth A O Dimba; Peggy Gronsdahl; Abby White; Helen S L Chan; Brenda L Gallie
Journal:  Lancet       Date:  2012-03-12       Impact factor: 79.321

Review 5.  Pluripotent stem cells in disease modelling and drug discovery.

Authors:  Yishai Avior; Ido Sagi; Nissim Benvenisty
Journal:  Nat Rev Mol Cell Biol       Date:  2016-01-28       Impact factor: 94.444

6.  Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients.

Authors:  Wen-Li Deng; Mei-Ling Gao; Xin-Lan Lei; Ji-Neng Lv; Huan Zhao; Kai-Wen He; Xi-Xi Xia; Ling-Yun Li; Yu-Chen Chen; Yan-Ping Li; Deng Pan; Tian Xue; Zi-Bing Jin
Journal:  Stem Cell Reports       Date:  2018-03-08       Impact factor: 7.765

7.  Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa.

Authors:  Adriana Buskin; Lili Zhu; Valeria Chichagova; Basudha Basu; Sina Mozaffari-Jovin; David Dolan; Alastair Droop; Joseph Collin; Revital Bronstein; Sudeep Mehrotra; Michael Farkas; Gerrit Hilgen; Kathryn White; Kuan-Ting Pan; Achim Treumann; Dean Hallam; Katarzyna Bialas; Git Chung; Carla Mellough; Yuchun Ding; Natalio Krasnogor; Stefan Przyborski; Simon Zwolinski; Jumana Al-Aama; Sameer Alharthi; Yaobo Xu; Gabrielle Wheway; Katarzyna Szymanska; Martin McKibbin; Chris F Inglehearn; David J Elliott; Susan Lindsay; Robin R Ali; David H Steel; Lyle Armstrong; Evelyne Sernagor; Henning Urlaub; Eric Pierce; Reinhard Lührmann; Sushma-Nagaraja Grellscheid; Colin A Johnson; Majlinda Lako
Journal:  Nat Commun       Date:  2018-10-12       Impact factor: 14.919

8.  Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform.

Authors:  Kevin Achberger; Christopher Probst; Jasmin Haderspeck; Sylvia Bolz; Julia Rogal; Johanna Chuchuy; Marina Nikolova; Virginia Cora; Lena Antkowiak; Wadood Haq; Nian Shen; Katja Schenke-Layland; Marius Ueffing; Stefan Liebau; Peter Loskill
Journal:  Elife       Date:  2019-08-27       Impact factor: 8.140

9.  Precision Medicine: Genetic Repair of Retinitis Pigmentosa in Patient-Derived Stem Cells.

Authors:  Alexander G Bassuk; Andrew Zheng; Yao Li; Stephen H Tsang; Vinit B Mahajan
Journal:  Sci Rep       Date:  2016-01-27       Impact factor: 4.379

10.  In Vivo CRISPR/Cas9 Gene Editing Corrects Retinal Dystrophy in the S334ter-3 Rat Model of Autosomal Dominant Retinitis Pigmentosa.

Authors:  Benjamin Bakondi; Wenjian Lv; Bin Lu; Melissa K Jones; Yuchun Tsai; Kevin J Kim; Rachelle Levy; Aslam Abbasi Akhtar; Joshua J Breunig; Clive N Svendsen; Shaomei Wang
Journal:  Mol Ther       Date:  2015-12-15       Impact factor: 11.454
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