Amit Bansal1, Preethi Jeyaraman2, S K Gupta1, Nitin Dayal3, Rahul Naithani2. 1. Pharmaceutical Sciences and Research University New Delhi, India. 2. Division of Hematology and Bone Marrow Transplant, Max Super-Speciality Hospital Saket, New Delhi, India. 3. Department of Lab Medicine, Max Super-Speciality Hospital Saket, New Delhi, India.
Abstract
BACKGROUND: Infections are major contributor to morbidity and mortality in patients undergoing bone marrow transplant (BMT). OBJECTIVE: To assess role of serum procalcitonin (PCT) as a useful biomarker for the infections and outcomes in these patients. METHODS: Retrospective observational study. RESULTS: Total 47 patients with febrile episodes were enrolled. Twenty patients underwent autologous BMT and 27 underwent allogeneic BMT. Bacterial infections were documented in 18/47 (38%) patients. Forty patients were neutropenic. The median fever duration was 10 days (range 3-30 days) in positive procalcitonin level group whereas it was 4 days (range 1-18) in negative group. This was statistically significant (P=0.000). Procalcitonin levels were high in 8/9 episodes of sepsis (P=0.029). Intensive care unit transfers and death were significantly higher in PCT positive group as compared to PCT negative group. CONCLUSION: Serum procalcitonin levels provide prognostic information of worse outcome in patients undergoing HSCT. AJBR
BACKGROUND:Infections are major contributor to morbidity and mortality in patients undergoing bone marrow transplant (BMT). OBJECTIVE: To assess role of serum procalcitonin (PCT) as a useful biomarker for the infections and outcomes in these patients. METHODS: Retrospective observational study. RESULTS: Total 47 patients with febrile episodes were enrolled. Twenty patients underwent autologous BMT and 27 underwent allogeneic BMT. Bacterial infections were documented in 18/47 (38%) patients. Forty patients were neutropenic. The median fever duration was 10 days (range 3-30 days) in positive procalcitonin level group whereas it was 4 days (range 1-18) in negative group. This was statistically significant (P=0.000). Procalcitonin levels were high in 8/9 episodes of sepsis (P=0.029). Intensive care unit transfers and death were significantly higher in PCT positive group as compared to PCT negative group. CONCLUSION: Serum procalcitonin levels provide prognostic information of worse outcome in patients undergoing HSCT. AJBR
Authors: K S R Massaro; R Macedo; B S de Castro; F Dulley; M S Oliveira; M A S Yasuda; A S Levin; S F Costa Journal: Infection Date: 2014-09-30 Impact factor: 3.553
Authors: M Sato; H Nakasone; K Terasako-Saito; K Sakamoto; R Yamazaki; Y Tanaka; Y Akahoshi; H Nakano; T Ugai; H Wada; R Yamasaki; Y Ishihara; K Kawamura; M Ashizawa; S-i Kimura; M Kikuchi; A Tanihara; J Kanda; S Kako; J Nishida; Y Kanda Journal: Bone Marrow Transplant Date: 2014-01-13 Impact factor: 5.483
Authors: Pedro Puerta-Alcalde; Celia Cardozo; Francesc Marco; Maria Suárez-Lledó; Estela Moreno; Laura Morata; Francesc Fernández-Avilés; Gonzalo Gutiérrez-Garcia; Mariana Chumbita; Laura Rosiñol; Jose Antonio Martínez; Carmen Martínez; Josep Mensa; Álvaro Urbano; Montserrat Rovira; Alex Soriano; Carolina Garcia-Vidal Journal: Bone Marrow Transplant Date: 2019-09-30 Impact factor: 5.483