Literature DB >> 33489192

A pathogenic germline BRCA2 variant in a patient with hypopharyngeal squamous cell carcinoma.

Tatiana Correa1, Douglas E Laux2, Henry T Hoffman1.   

Abstract

Pathogenic germline BRCA2 variants may be associated with an increased risk of hypopharyngeal squamous cell carcinoma that is more responsive to chemoradiation and chemotherapeutics targeting defective double-strand DNA repair.
© 2020 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd.

Entities:  

Keywords:  genetics; head and neck; molecular targeted therapies; oncology; pharmacology

Year:  2020        PMID： 33489192      PMCID： PMC7813105          DOI： 10.1002/ccr3.3548

Source DB:  PubMed          Journal:  Clin Case Rep        ISSN： 2050-0904


  5 in total

Review 1.  Natural History of Treated and Untreated Hypopharyngeal Cancer.

Authors:  Hans E Eckel; Patrick J Bradley
Journal:  Adv Otorhinolaryngol       Date:  2019-02-12

2.  The FA/BRCA Pathway Identified as the Major Predictor of Cisplatin Response in Head and Neck Cancer by Functional Genomics.

Authors:  Sanne R Martens-de Kemp; Arjen Brink; Ida H van der Meulen; Renée X de Menezes; Dennis E Te Beest; C René Leemans; Victor W van Beusechem; Boudewijn J M Braakhuis; Ruud H Brakenhoff
Journal:  Mol Cancer Ther       Date:  2016-12-15       Impact factor: 6.261

3.  Cancer risks in BRCA2 families: estimates for sites other than breast and ovary.

Authors:  C J van Asperen; R M Brohet; E J Meijers-Heijboer; N Hoogerbrugge; S Verhoef; H F A Vasen; M G E M Ausems; F H Menko; E B Gomez Garcia; J G M Klijn; F B L Hogervorst; J C van Houwelingen; L J van't Veer; M A Rookus; F E van Leeuwen
Journal:  J Med Genet       Date:  2005-09       Impact factor: 6.318

4.  Assessing the spectrum of germline variation in Fanconi anemia genes among patients with head and neck carcinoma before age 50.

Authors:  Settara C Chandrasekharappa; Steven B Chinn; Frank X Donovan; Naweed I Chowdhury; Aparna Kamat; Adebowale A Adeyemo; James W Thomas; Meghana Vemulapalli; Caroline S Hussey; Holly H Reid; James C Mullikin; Qingyi Wei; Erich M Sturgis
Journal:  Cancer       Date:  2017-07-05       Impact factor: 6.860

5.  Platinum response characteristics of patients with pancreatic ductal adenocarcinoma and a germline BRCA1, BRCA2 or PALB2 mutation.

Authors:  Max M Wattenberg; Daniella Asch; Shun Yu; Peter J O'Dwyer; Susan M Domchek; Katherine L Nathanson; Mark A Rosen; Gregory L Beatty; Evan S Siegelman; Kim A Reiss
Journal:  Br J Cancer       Date:  2019-12-02       Impact factor: 7.640
  5 in total

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