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Literature DB >> 33488832

Progress in the total synthesis of inthomycins.

Abstract

The inthomycin family of antibiotics, isolated from Streptomyces strains, are interesting molecules for synthesis due to their characteristic common oxazole polyene chiral allylic β-hydroxycarbonyl fragments and significant biological activities. The full structural motif of the inthomycins is found in several more complex natural products including the oxazolomycins, 16-methyloxazolomycin, curromycins A and B, and KSM-2690. This review summarises the application of various efforts towards the synthesis of inthomycins and their analogues systematically.

Entities: Chemical Disease Species

Keywords: Stille coupling; antibiotics; inthomycins; oxazololomycin; total synthesis

Year: 2021 PMID： 33488832 PMCID： PMC7801802 DOI： 10.3762/bjoc.17.7

Source DB: PubMed Journal: Beilstein J Org Chem ISSN： 1860-5397 Impact factor: 2.883

37 in total

1. A Method for Iodination of Oxazoles at C-4 via 2-Lithiooxazoles.

Authors: Edwin Vedejs; Leza M. Luchetta
Journal: J Org Chem Date: 1999-02-05 Impact factor: 4.354

2. Significant enhancement of the Stille reaction with a new combination of reagents-copper(I) iodide with cesium fluoride.

Authors: Simon P H Mee; Victor Lee; Jack E Baldwin
Journal: Chemistry Date: 2005-05-20 Impact factor: 5.236

Review 3. Total synthesis of oxazolomycins.

Authors: Jun Ishihara; Susumi Hatakeyama
Journal: Chem Rec Date: 2014-07-28 Impact factor: 6.771

4. New antibiotics phthoxazolins B, C and D produced by Streptomyces sp. KO-7888.

Authors: K Shiomi; N Arai; M Shinose; Y Takahashi; H Yoshida; J Iwabuchi; Y Tanaka; S Omura
Journal: J Antibiot (Tokyo) Date: 1995-07 Impact factor: 2.649

5. Carreira alkynylations with paraformaldehyde. a mild and convenient protocol for the hydroxymethylation of complex base-sensitive terminal acetylenes via alkynylzinc triflates.

Authors: Karl J Hale; Ziyue Xiong; Liping Wang; Soraya Manaviazar; Ryan Mackle
Journal: Org Lett Date: 2014-12-24 Impact factor: 6.005

Review 6. The expanded horizon for microbial metabolites--a review.

Authors: S Omura
Journal: Gene Date: 1992-06-15 Impact factor: 3.688

7. Phthoxazolin A, a specific inhibitor of cellulose biosynthesis from microbial origin. I. Discovery, taxonomy of producing microorganism, fermentation, and biological activity.

Authors: Y Tanaka; I Kanaya; Y Takahashi; M Shinose; H Tanaka; S Omura
Journal: J Antibiot (Tokyo) Date: 1993-08 Impact factor: 2.649