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Literature DB >> 33488760

Diarylalkanoids as Potent Tyrosinase Inhibitors from the Stems of Semecarpus caudata.

Phu H Dang^1,2, Tho H Le^1,2, Truong N V Do^1,2, Hai X Nguyen^1,2, Mai T T Nguyen^1,2,3, Nhan T Nguyen^1,2,3.

Abstract

From a CHCl3-soluble extract of the stems of Semecarpus caudata (Anacardiaceae), two new diarylalkanoids, semedienone (1) and semetrienone (2), were isolated. Their structures were elucidated based on NMR spectroscopic data interpretation. These compounds possess strong tyrosinase inhibitory activity with the IC50 values of 0.033 and 0.11 μM, respectively. Docking studies of 1 and 2 with oxy-tyrosinase were carried out to analyze their interactions. Accordingly, semedienone (1) showed good interactions with the peroxide group and amino acid residues. The biosynthesis of the isolated diarylalkanoids was proposed.

Entities: Chemical Disease Gene

Year: 2021 PMID： 33488760 PMCID： PMC7801053 DOI： 10.1155/2021/8872920

Source DB: PubMed Journal: Evid Based Complement Alternat Med ISSN： 1741-427X Impact factor: 2.629

20 in total

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