Choline derivatives immobilized on silica to catalyze transesterification reaction for production of glycerophosphocholine.

Choline derivatives were covalently immobilized on the surface of γ -aminated silica. The obtained immobilized choline derivative was then successfully used for a transesterification reaction to produce glycerophosphocholine (GPC). Fourier transform infrared analysis and thermogravimetric analysis/differential thermal gravimetry indicated that the surface of the γ -aminated silica was covered by choline derivatives and the highest immobilization amount reached 1.1 mmol/g under optimal conditions. More importantly, the highest yield of GPC reached 97.9% during transesterification. With regard to GPC in food or medicine for human use, the immobilization technology can avoid catalyst contamination of the product and increase the safety of the product. The recyclability and stability of the immobilized choline derivative were excellent, as demonstrated by its use 20 times without any loss of productivity. A first-order kinetic model was employed and the relevant parameters were calculated to investigate kinetic characteristics of transesterification.