Larissa Cristina Fontenelle1, Mayara Monte Feitosa2, Taynáh Emannuelle Coelho Freitas3, Juliana Soares Severo4, Jennifer Beatriz Silva Morais5, Gilberto Simeone Henriques6, Francisco Erasmo Oliveira7, José Machado Moita Neto8, Dilina do Nascimento Marreiro9. 1. Department of Nutrition, Federal University of Piauí, Campus Ministro Petrônio Portella, Teresina, Piauí, 64049-550, Brazil. Electronic address: larissacris.f@hotmail.com. 2. Department of Nutrition, Federal University of Piauí, Campus Ministro Petrônio Portella, Teresina, Piauí, 64049-550, Brazil. Electronic address: mayarafeitosa@hotmail.com. 3. Department of Nutrition, Federal University of Piauí, Campus Ministro Petrônio Portella, Teresina, Piauí, 64049-550, Brazil. Electronic address: taynahcoelho@outlook.com. 4. Department of Nutrition, Federal University of Piauí, Campus Ministro Petrônio Portella, Teresina, Piauí, 64049-550, Brazil. Electronic address: ju_ssevero@hotmail.com. 5. Department of Nutrition, Federal University of Piauí, Campus Ministro Petrônio Portella, Teresina, Piauí, 64049-550, Brazil. Electronic address: jenniferbeatriz.morais@gmail.com. 6. School of Nursing, Department of Nutrition, Federal University of Minas Gerais, 6627 Av. Pres. Antônio Carlos, Belo Horizonte, Minas Gerais, 31270-901, Brazil. Electronic address: gilberto.simeone@gmail.com. 7. Med Imagem Clinical Laboratory, Rua Paissandu 1862, Centro Sul, CEP, Teresina, Piauí, 64001-120, Brazil. Electronic address: erasmo@medimagem.com.br. 8. Department of Chemistry, Federal University of Piauí, Campus Ministro Petrônio Portella, Teresina, Piauí, 64049-550, Brazil. Electronic address: jmoita@pq.cnpq.br. 9. Department of Nutrition, Federal University of Piauí, Campus Ministro Petrônio Portella, Teresina, Piauí, 64049-550, Brazil. Electronic address: dilina.marreiro@gmail.com.
Abstract
BACKGROUND AND AIMS: Studies have been conducted with the purpose of elucidating thyroid gland dysfunction in obesity, however the contributing factors for such dysfunction are not yet fully understood. Selenium is notable for its role in thyrocyte protection against oxidative damage and control of thyroid hormone synthesis. In addition, subjects with obesity may exhibit alterations in the selenium homeostasis. Therefore, the present study aimed to examine the selenium status and its relationship with serum thyroid hormone levels in obese women. METHODS: This cross-sectional study included 69 euthyroid women, aged between 18 and 50 years, who were divided in two groups: an obese group (n = 35) and a control group with women of normal weight (n = 34). Selenium intake was assessed by three-day diet records and analyzed using NutWin software version 1.5. Plasma, erythrocyte, and urinary selenium levels were determined using inductively coupled plasma optical emission spectrometry. Testing for thyroid hormones and thyroid autoantibodies was performed based on chemiluminescence. RESULTS: The median dietary selenium content was adequate according to the recommendations, with no statistical difference between groups. Obese women had reduced plasma and erythrocyte selenium levels compared to the control group, although selenium concentration in erythrocytes was adequate within the normal range for both groups. There was no significant difference between the urinary selenium concentrations in the subjects; however, the mineral clearance was higher in the obese group. Free triiodothyronine (fT3) and free thyroxine (fT4) levels were higher in obese women with class II obesity when compared to the control group. There was a negative correlation between plasma selenium and serum fT4 levels. CONCLUSIONS: Obese women showed impairment in selenium homeostasis, however, this fact did not seem to adversely affect thyroid metabolism.
BACKGROUND AND AIMS: Studies have been conducted with the purpose of elucidating thyroid gland dysfunction in obesity, however the contributing factors for such dysfunction are not yet fully understood. Selenium is notable for its role in thyrocyte protection against oxidative damage and control of thyroid hormone synthesis. In addition, subjects with obesity may exhibit alterations in the selenium homeostasis. Therefore, the present study aimed to examine the selenium status and its relationship with serum thyroid hormone levels in obesewomen. METHODS: This cross-sectional study included 69 euthyroid women, aged between 18 and 50 years, who were divided in two groups: an obese group (n = 35) and a control group with women of normal weight (n = 34). Selenium intake was assessed by three-day diet records and analyzed using NutWin software version 1.5. Plasma, erythrocyte, and urinary selenium levels were determined using inductively coupled plasma optical emission spectrometry. Testing for thyroid hormones and thyroid autoantibodies was performed based on chemiluminescence. RESULTS: The median dietary selenium content was adequate according to the recommendations, with no statistical difference between groups. Obesewomen had reduced plasma and erythrocyte selenium levels compared to the control group, although selenium concentration in erythrocytes was adequate within the normal range for both groups. There was no significant difference between the urinary selenium concentrations in the subjects; however, the mineral clearance was higher in the obese group. Free triiodothyronine (fT3) and free thyroxine (fT4) levels were higher in obesewomen with class II obesity when compared to the control group. There was a negative correlation between plasma selenium and serum fT4 levels. CONCLUSIONS:Obesewomen showed impairment in selenium homeostasis, however, this fact did not seem to adversely affect thyroid metabolism.
Authors: Larissa Cristina Fontenelle; Mickael de Paiva Sousa; Loanne Rocha Dos Santos; Bruna Emanuele Pereira Cardoso; Thayanne Gabryelle Visgueira de Sousa; Tamires da Cunha Soares; Stéfany Rodrigues de Sousa Melo; Jennifer Beatriz Silva Morais; Thaline Milany da Silva Dias; Francisco Erasmo de Oliveira; Débora Cavalcante Braz; João Marcelo de Castro E Sousa; Francisco Leonardo Torres-Leal; Gilberto Simeone Henriques; Dilina do Nascimento Marreiro Journal: Biol Trace Elem Res Date: 2022-04-06 Impact factor: 3.738