Literature DB >> 33486628

Activation of the extracellular signal-regulated kinase pathway is required for replication of Newcastle disease virus.

Jie Ni1,2, Shunlin Hu1,2,3,4, Xiaoquan Wang1,2,3,4, Xiaowen Liu1,2,3,4, Zenglei Hu5,6, Xiufan Liu7,8.   

Abstract

Replication of Newcastle disease virus (NDV) is regulated by various host mechanisms, but the role of the extracellular signal-regulated kinase (ERK) pathway in regulating NDV replication is an open question. In this study, the relationship between the ERK pathway and NDV replication was investigated. NDV activated the ERK signaling in chicken embryo fibroblasts at the late stage of infection, correlating to expression of viral proteins. Specific blockage of the ERK pathway activation significantly decreased the transcription and translation levels of viral genes as well as virus replication and the cytopathogenic effect caused by NDV. Our results demonstrate that activation of the ERK pathway is required for NDV replication.

Entities:  

Mesh：

Substances：

Year:  2021        PMID： 33486628     DOI： 10.1007/s00705-020-04938-3

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  33 in total

1.  Genotypic and pathogenic characterization of genotype VII Newcastle disease viruses isolated from commercial farms in Egypt and evaluation of heterologous antibody responses.

Authors:  A M Saad; Ahmed Samy; M A Soliman; A Arafa; A Zanaty; M K Hassan; A H Sultan; A I Bazid; A H Hussein
Journal:  Arch Virol       Date:  2017-03-25       Impact factor: 2.574

2.  Molecular characterization of chicken-derived genotype VIId Newcastle disease virus isolates in China during 2005-2012 reveals a new length in hemagglutinin-neuraminidase.

Authors:  Yuan-Yuan Zhang; Meng-Yu Shao; Xiao-Hui Yu; Jing Zhao; Guo-Zhong Zhang
Journal:  Infect Genet Evol       Date:  2013-12-11       Impact factor: 3.342

3.  Roles of the fusion and hemagglutinin-neuraminidase proteins in replication, tropism, and pathogenicity of avian paramyxoviruses.

Authors:  Shin-Hee Kim; Madhuri Subbiah; Arthur S Samuel; Peter L Collins; Siba K Samal
Journal:  J Virol       Date:  2011-06-15       Impact factor: 5.103

4.  A recombinant newcastle disease virus with low-level V protein expression is immunogenic and lacks pathogenicity for chicken embryos.

Authors:  T Mebatsion; S Verstegen; L T De Vaan; A Römer-Oberdörfer; C C Schrier
Journal:  J Virol       Date:  2001-01       Impact factor: 5.103

5.  Taxonomy of the order Mononegavirales: update 2019.

Authors:  Gaya K Amarasinghe; María A Ayllón; Yīmíng Bào; Christopher F Basler; Sina Bavari; Kim R Blasdell; Thomas Briese; Paul A Brown; Alexander Bukreyev; Anne Balkema-Buschmann; Ursula J Buchholz; Camila Chabi-Jesus; Kartik Chandran; Chiara Chiapponi; Ian Crozier; Rik L de Swart; Ralf G Dietzgen; Olga Dolnik; Jan F Drexler; Ralf Dürrwald; William G Dundon; W Paul Duprex; John M Dye; Andrew J Easton; Anthony R Fooks; Pierre B H Formenty; Ron A M Fouchier; Juliana Freitas-Astúa; Anthony Griffiths; Roger Hewson; Masayuki Horie; Timothy H Hyndman; Dàohóng Jiāng; Elliott W Kitajima; Gary P Kobinger; Hideki Kondō; Gael Kurath; Ivan V Kuzmin; Robert A Lamb; Antonio Lavazza; Benhur Lee; Davide Lelli; Eric M Leroy; Jiànróng Lǐ; Piet Maes; Shin-Yi L Marzano; Ana Moreno; Elke Mühlberger; Sergey V Netesov; Norbert Nowotny; Are Nylund; Arnfinn L Økland; Gustavo Palacios; Bernadett Pályi; Janusz T Pawęska; Susan L Payne; Alice Prosperi; Pedro Luis Ramos-González; Bertus K Rima; Paul Rota; Dennis Rubbenstroth; Mǎng Shī; Peter Simmonds; Sophie J Smither; Enrica Sozzi; Kirsten Spann; Mark D Stenglein; David M Stone; Ayato Takada; Robert B Tesh; Keizō Tomonaga; Noël Tordo; Jonathan S Towner; Bernadette van den Hoogen; Nikos Vasilakis; Victoria Wahl; Peter J Walker; Lin-Fa Wang; Anna E Whitfield; John V Williams; F Murilo Zerbini; Tāo Zhāng; Yong-Zhen Zhang; Jens H Kuhn
Journal:  Arch Virol       Date:  2019-07       Impact factor: 2.574

6.  The viral replication complex is associated with the virulence of Newcastle disease virus.

Authors:  J C F M Dortmans; P J M Rottier; G Koch; B P H Peeters
Journal:  J Virol       Date:  2010-07-21       Impact factor: 5.103

7.  Newcastle disease virus: macromolecules and opportunities.

Authors:  K Yusoff; W S Tan
Journal:  Avian Pathol       Date:  2001-10       Impact factor: 3.378

8.  Role of untranslated regions of the hemagglutinin-neuraminidase gene in replication and pathogenicity of newcastle disease virus.

Authors:  Yongqi Yan; Subrat N Rout; Shin-Hee Kim; Siba K Samal
Journal:  J Virol       Date:  2009-03-25       Impact factor: 5.103

9.  Mutations in the cytoplasmic domain of the Newcastle disease virus fusion protein confer hyperfusogenic phenotypes modulating viral replication and pathogenicity.

Authors:  Sweety Samal; Sunil K Khattar; Anandan Paldurai; Senthilkumar Palaniyandi; Xiaoping Zhu; Peter L Collins; Siba K Samal
Journal:  J Virol       Date:  2013-07-10       Impact factor: 5.103

Review 10.  Newcastle disease vaccines-A solved problem or a continuous challenge?

Authors:  Kiril M Dimitrov; Claudio L Afonso; Qingzhong Yu; Patti J Miller
Journal:  Vet Microbiol       Date:  2016-12-16       Impact factor: 3.293
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.