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Literature DB >> 33484711

Na⁺ and K⁺ channels: history and structure.

Clay M Armstrong¹, Stephen Hollingworth².

Abstract

In this perspective, we discuss the physiological roles of Na and K channels, emphasizing the importance of the K channel for cellular homeostasis in animal cells and of Na and K channels for cellular signaling. We consider the structural basis of Na and K channel gating in light of recent structural and electrophysiological findings.

Entities: Chemical

Mesh：

Substances：
Ions
Sodium

Year: 2021 PMID： 33484711 PMCID： PMC8008242 DOI： 10.1016/j.bpj.2021.01.013

Source DB: PubMed Journal: Biophys J ISSN： 0006-3495 Impact factor: 4.033

75 in total

1. The Na/K pump, Cl ion, and osmotic stabilization of cells.

Authors: Clay M Armstrong
Journal: Proc Natl Acad Sci U S A Date: 2003-05-01 Impact factor: 11.205

2. Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB.

Authors: W N Zagotta; T Hoshi; R W Aldrich
Journal: Science Date: 1990-10-26 Impact factor: 47.728

3. Voltage sensor of Kv1.2: structural basis of electromechanical coupling.

Authors: Stephen B Long; Ernest B Campbell; Roderick Mackinnon
Journal: Science Date: 2005-07-07 Impact factor: 47.728

4. Studies on the axon membrane; a new method.

Authors: G MARMONT
Journal: J Cell Comp Physiol Date: 1949-12

5. Identification of an intracellular peptide segment involved in sodium channel inactivation.

Authors: P M Vassilev; T Scheuer; W A Catterall
Journal: Science Date: 1988-09-23 Impact factor: 47.728

6. Chance and design in electrophysiology: an informal account of certain experiments on nerve carried out between 1934 and 1952.

Authors: A L Hodgkin
Journal: J Physiol Date: 1976-12 Impact factor: 5.182

1. Effects of JZTX-V on the wild type Kv4.3 Expressed in HEK293T and Molecular Determinants in the Voltage-sensing Domains of Kv4.3 Interacting with JZTX-V.

Authors: Xu Dehong; Wu Wenmei; Hong Siqin; Zeng Peng; Wang Xianchun; Zeng Xiongzhi
Journal: Channels (Austin) Date: 2022-12 Impact factor: 3.493

1 in total

Na⁺ and K⁺ channels: history and structure.

1. The Na/K pump, Cl ion, and osmotic stabilization of cells.

2. Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB.

3. Voltage sensor of Kv1.2: structural basis of electromechanical coupling.

4. Studies on the axon membrane; a new method.

5. Identification of an intracellular peptide segment involved in sodium channel inactivation.

6. Chance and design in electrophysiology: an informal account of certain experiments on nerve carried out between 1934 and 1952.

7. Resurgent sodium current and action potential formation in dissociated cerebellar Purkinje neurons.

8. Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation.

9. C-type inactivation of voltage-gated K+ channels: pore constriction or dilation?

10. The crystal structure of a voltage-gated sodium channel.

1. Effects of JZTX-V on the wild type Kv4.3 Expressed in HEK293T and Molecular Determinants in the Voltage-sensing Domains of Kv4.3 Interacting with JZTX-V.