Literature DB >> 33484373

Factor Xa: Thrombokinase from Paul Morawitz to J Haskell Milstone.

Leonard M Milstone1.   

Abstract

In 1904 Paul Morawitz postulated that an enzyme, which he named thrombokinase, would be the primary activator of prothrombin. Fifty years passed before J Haskell Milstone isolated, purified and functionally characterized the enzyme we now call Factor Xa. This essay summarizes Milstone's work on thrombokinase, and finds context for why his efforts succeeded while others struggled.
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.

Entities:  

Keywords:  Coagulation; Enzyme; Factor X; Protein purification; Thrombokinase; Zymogen

Mesh：

Substances：

Year:  2021        PMID： 33484373     DOI： 10.1007/s11239-021-02387-6

Source DB:  PubMed          Journal:  J Thromb Thrombolysis        ISSN： 0929-5305            Impact factor:   2.300


  13 in total

1.  THROMBOKINASE AS PRIME ACTIVATOR OF PROTHROMBIN: HISTORICAL PERSPECTIVES AND PRESENT STATUS.

Authors:  J H MILSTONE
Journal:  Fed Proc       Date:  1964 Jul-Aug

2.  Chromatography of blood thrombokinase on 'DEAE'-cellulose.

Authors:  J H MILSTONE
Journal:  Nature       Date:  1960-09-24       Impact factor: 49.962

3.  Nomenclature of blood clotting factors; acceptance by the International Committee on nomenclature of four factors, their characteristics and international number.

Authors:  I S WRIGHT
Journal:  Can Med Assoc J       Date:  1958-04-15       Impact factor: 8.262

4.  Prothrombokinase and the Three Stages of Blood Coagulation.

Authors:  J H Milstone
Journal:  Science       Date:  1947-12-05       Impact factor: 47.728

5.  Mechanism of bovine prothrombin activation by an insoluble preparation of bovine factor X a (thrombokinase).

Authors:  K S Stenn; E R Blout
Journal:  Biochemistry       Date:  1972-11-21       Impact factor: 3.162

6.  Chromatographic analysis of the activation of human prothrombin with human thrombokinase.

Authors:  D L Aronson; D Ménaché
Journal:  Biochemistry       Date:  1966-08       Impact factor: 3.162

7.  Fractionation of plasma globulin for prothrombin, thrombokinase, and accessory thromboplastin.

Authors:  J H MILSTONE
Journal:  J Gen Physiol       Date:  1951-09       Impact factor: 4.086

8.  Bovine serum as a complement for the combined effects of thrombokinase and cephalin.

Authors:  J H MILSTONE
Journal:  Yale J Biol Med       Date:  1952-12

9.  OUTSTANDING CHARACTERISTICS OF THROMBOKINASE ISOLATED FROM BOVINE PLASMA.

Authors:  J H MILSTONE; N OULIANOFF; V K MILSTONE
Journal:  J Gen Physiol       Date:  1963-11       Impact factor: 4.086

10.  Three-stage analysis of blood coagulation.

Authors:  J H MILSTONE
Journal:  J Gen Physiol       Date:  1948-03-20       Impact factor: 4.086
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.