| Literature DB >> 33483585 |
Sofia Lage-Vickers1,2, Juan Bizzotto1,2, Maria Pia Valacco1,2, Pablo Sanchis1,2, Sergio Nemirovsky1,2, Estefania Labanca3, Carlos Scorticati4, Osvaldo Mazza4, Antonina Mitrofanova5, Nora Navone3, Elba Vazquez1,2, Javier Cotignola6,7, Geraldine Gueron8,9.
Abstract
Some prostate cancers (PCas) are histo-pathologically grouped within the same Gleason Grade (GG), but can differ significantly in outcome. Herein, we aimed at identifying molecular biomarkers that could improve risk prediction in PCa. LC ESI-MS/MS was performed on human PCa and benign prostatic hyperplasia (BPH) tissues and peptide data was integrated with omic analyses. We identified high YWHAZ and NDRG1 expression to be associated with poor PCa prognosis considering all Gleason scores (GS). YWHAZ and NDRG1 defined two subpopulations of PCa patients with high and intermediate risk of death. Multivariable analyses confirmed their independence from GS. ROC analysis unveiled that YWHAZ outperformed GS beyond 60 months post-diagnosis. The genomic analysis of PCa patients with YWHAZ amplification, or increased mRNA or protein levels, revealed significant alterations in key DNA repair genes. We hereby state the relevance of YWHAZ in PCa, showcasing its role as an independent strong predictor of aggressiveness.Entities:
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Year: 2021 PMID： 33483585 PMCID： PMC7822895 DOI： 10.1038/s42003-020-01645-2
Source DB: PubMed Journal: Commun Biol ISSN： 2399-3642