Literature DB >> 33483467

Deubiquitylating enzymes in neuronal health and disease.

Fatima Amer-Sarsour1, Alina Kordonsky2, Yevgeny Berdichevsky1, Gali Prag3,4, Avraham Ashkenazi5,6.   

Abstract

Ubiquitylation and deubiquitylation play a pivotal role in protein homeostasis (proteostasis). Proteostasis shapes the proteome landscape in the human brain and its impairment is linked to neurodevelopmental and neurodegenerative disorders. Here we discuss the emerging roles of deubiquitylating enzymes in neuronal function and survival. We provide an updated perspective on the genetics, physiology, structure, and function of deubiquitylases in neuronal health and disease.

Entities:  

Year:  2021        PMID： 33483467      PMCID： PMC7822931          DOI： 10.1038/s41419-020-03361-5

Source DB:  PubMed          Journal:  Cell Death Dis            Impact factor:   8.469


  98 in total

1.  Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis.

Authors:  Vaibhav Kapuria; Luke F Peterson; Dexing Fang; William G Bornmann; Moshe Talpaz; Nicholas J Donato
Journal:  Cancer Res       Date:  2010-11-02       Impact factor: 12.701

2.  USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria.

Authors:  Christian N Cunningham; Joshua M Baughman; Lilian Phu; Joy S Tea; Christine Yu; Mary Coons; Donald S Kirkpatrick; Baris Bingol; Jacob E Corn
Journal:  Nat Cell Biol       Date:  2015-01-26       Impact factor: 28.824

3.  The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.

Authors:  Yichin Liu; Lara Fallon; Hilal A Lashuel; Zhihua Liu; Peter T Lansbury
Journal:  Cell       Date:  2002-10-18       Impact factor: 41.582

Review 4.  Cellular quality control by the ubiquitin-proteasome system and autophagy.

Authors:  Christian Pohl; Ivan Dikic
Journal:  Science       Date:  2019-11-14       Impact factor: 47.728

5.  Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease.

Authors:  Scott M Wilson; Bula Bhattacharyya; Rivka A Rachel; Vincenzo Coppola; Lino Tessarollo; Deborah B Householder; Colin F Fletcher; Richard J Miller; Neal G Copeland; Nancy A Jenkins
Journal:  Nat Genet       Date:  2002-10-07       Impact factor: 38.330

6.  USP7 Acts as a Molecular Rheostat to Promote WASH-Dependent Endosomal Protein Recycling and Is Mutated in a Human Neurodevelopmental Disorder.

Authors:  Yi-Heng Hao; Michael D Fountain; Klementina Fon Tacer; Fan Xia; Weimin Bi; Sung-Hae L Kang; Ankita Patel; Jill A Rosenfeld; Cédric Le Caignec; Bertrand Isidor; Ian D Krantz; Sarah E Noon; Jean P Pfotenhauer; Thomas M Morgan; Rocio Moran; Robert C Pedersen; Margarita S Saenz; Christian P Schaaf; Patrick Ryan Potts
Journal:  Mol Cell       Date:  2015-09-10       Impact factor: 17.970

7.  Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown.

Authors:  A Hershko; H Heller; S Elias; A Ciechanover
Journal:  J Biol Chem       Date:  1983-07-10       Impact factor: 5.157

8.  Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde.

Authors:  Min Hu; Pingwei Li; Muyang Li; Wenyu Li; Tingting Yao; Jia-Wei Wu; Wei Gu; Robert E Cohen; Yigong Shi
Journal:  Cell       Date:  2002-12-27       Impact factor: 41.582

9.  Structural insights into the activation of USP46 by WDR48 and WDR20.

Authors:  Hanwen Zhu; Tianlong Zhang; Fang Wang; Jun Yang; Jianping Ding
Journal:  Cell Discov       Date:  2019-07-02       Impact factor: 10.849

10.  Deubiquitinase Usp8 regulates α-synuclein clearance and modifies its toxicity in Lewy body disease.

Authors:  Zoi Alexopoulou; Johannes Lang; Rebecca M Perrett; Myriam Elschami; Madeleine E D Hurry; Hyoung Tae Kim; Dimitra Mazaraki; Aron Szabo; Benedikt M Kessler; Alfred Lewis Goldberg; Olaf Ansorge; Tudor A Fulga; George K Tofaris
Journal:  Proc Natl Acad Sci U S A       Date:  2016-07-21       Impact factor: 11.205
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  3 in total

Review 1.  On the Study of Deubiquitinases: Using the Right Tools for the Job.

Authors:  Cody Caba; Azam Mohammadzadeh; Yufeng Tong
Journal:  Biomolecules       Date:  2022-05-14

Review 2.  Atypical Ubiquitination and Parkinson's Disease.

Authors:  Olga Buneeva; Alexei Medvedev
Journal:  Int J Mol Sci       Date:  2022-03-28       Impact factor: 5.923

Review 3.  Modulating the Ubiquitin-Proteasome System: A Therapeutic Strategy for Autoimmune Diseases.

Authors:  Dhananjay Yadav; Ji Yeon Lee; Nidhi Puranik; Pallavi S Chauhan; Vishal Chavda; Jun-O Jin; Peter C W Lee
Journal:  Cells       Date:  2022-03-24       Impact factor: 6.600
  3 in total

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