Literature DB >> 33482930

Integrin Linked Kinase (ILK) and its Role in Liver Pathobiology.

Nicole Martucci1, George K Michalopoulos1, Wendy M Mars1.   

Abstract

Integrin linked kinase (ILK) is a vital signaling protein ubiquitously expressed throughout the body. It binds to intracellular integrins to help promote signaling related to cell adhesion, apoptosis, proliferation, migration, and a plethora of other common cellular functions. In this review, ILKs role in the liver is detailed. Studies have shown ILK to be a major participant in hepatic ECM organization, liver regeneration, insulin resistance, and hepatocellular carcinoma.

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Year:  2021        PMID： 33482930      PMCID： PMC8201652          DOI： 10.3727/105221621X16113475275710

Source DB:  PubMed          Journal:  Gene Expr        ISSN： 1052-2166


  63 in total

1.  Integrin-linked kinase expression increases with prostate tumor grade.

Authors:  J R Graff; J A Deddens; B W Konicek; B M Colligan; B M Hurst; H W Carter; J H Carter
Journal:  Clin Cancer Res       Date:  2001-07       Impact factor: 12.531

2.  Akt phosphorylation is a risk factor for early disease recurrence and poor prognosis in hepatocellular carcinoma.

Authors:  Kazuaki Nakanishi; Michiie Sakamoto; Susumu Yamasaki; Satoru Todo; Setsuo Hirohashi
Journal:  Cancer       Date:  2005-01-15       Impact factor: 6.860

Review 3.  The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.

Authors:  S K Hanks; A M Quinn; T Hunter
Journal:  Science       Date:  1988-07-01       Impact factor: 47.728

4.  The pseudoactive site of ILK is essential for its binding to alpha-Parvin and localization to focal adhesions.

Authors:  Koichi Fukuda; Sudhiranjan Gupta; Ka Chen; Chuanyue Wu; Jun Qin
Journal:  Mol Cell       Date:  2009-12-11       Impact factor: 17.970

5.  Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival.

Authors:  Paul C McDonald; Arusha Oloumi; Julia Mills; Iveta Dobreva; Mykola Maidan; Virginia Gray; Elizabeth D Wederell; Marcel B Bally; Leonard J Foster; Shoukat Dedhar
Journal:  Cancer Res       Date:  2008-03-15       Impact factor: 12.701

6.  A lipidomic analysis of nonalcoholic fatty liver disease.

Authors:  Puneet Puri; Rebecca A Baillie; Michelle M Wiest; Faridoddin Mirshahi; Jayanta Choudhury; Onpan Cheung; Carol Sargeant; Melissa J Contos; Arun J Sanyal
Journal:  Hepatology       Date:  2007-10       Impact factor: 17.425

7.  Mapping the integrin-linked kinase interactome using SILAC.

Authors:  Iveta Dobreva; Andrew Fielding; Leonard J Foster; Shoukat Dedhar
Journal:  J Proteome Res       Date:  2008-03-10       Impact factor: 4.466

Review 8.  PKB/Akt: a key mediator of cell proliferation, survival and insulin responses?

Authors:  M A Lawlor; D R Alessi
Journal:  J Cell Sci       Date:  2001-08       Impact factor: 5.285

9.  Integrin-Linked Kinase Is Necessary for the Development of Diet-Induced Hepatic Insulin Resistance.

Authors:  Ashley S Williams; Elijah Trefts; Louise Lantier; Carrie A Grueter; Deanna P Bracy; Freyja D James; Ambra Pozzi; Roy Zent; David H Wasserman
Journal:  Diabetes       Date:  2016-11-29       Impact factor: 9.461

10.  Extracellular Matrix Molecular Remodeling in Human Liver Fibrosis Evolution.

Authors:  Andrea Baiocchini; Claudia Montaldo; Alice Conigliaro; Alessio Grimaldi; Virginia Correani; Francesco Mura; Fabiola Ciccosanti; Nicolina Rotiroti; Alessia Brenna; Marzia Montalbano; Gianpiero D'Offizi; Maria Rosaria Capobianchi; Riccardo Alessandro; Mauro Piacentini; Maria Eugenia Schininà; Bruno Maras; Franca Del Nonno; Marco Tripodi; Carmine Mancone
Journal:  PLoS One       Date:  2016-03-21       Impact factor: 3.240
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