Laurent Zieleskiewicz1,2, Alexandre Lopez3, Sami Hraiech4, Karine Baumstarck5, Bruno Pastene3, Mathieu Di Bisceglie6, Benjamin Coiffard4, Gary Duclos3, Alain Boussuges7,8, Xavier Bobbia9, Sharon Einav10, Laurent Papazian4, Marc Leone3. 1. Assistance Publique Hôpitaux de Marseille, Department of Anesthesiology and Intensive Care, Hôpital Nord, Aix Marseille University, 13015, Marseille, France. Laurent.zielekiewicz@ap-hm.fr. 2. Center for Cardiovascular and Nutrition Research (C2VN), INSERM, INRA, Aix Marseille Université, 13005, Marseille, France. Laurent.zielekiewicz@ap-hm.fr. 3. Assistance Publique Hôpitaux de Marseille, Department of Anesthesiology and Intensive Care, Hôpital Nord, Aix Marseille University, 13015, Marseille, France. 4. Assistance Publique Hôpitaux de Marseille, Service de Médecine Intensive - Réanimation, Hôpital Nord, Aix Marseille University, 13015, Marseille, France. 5. Centre D'Etudes et de Recherches sur les Services de Santé et Qualité, Faculté de Médecine, Aix-Marseille Université, 13005, Marseille, France. 6. Assistance Publique Hôpitaux de Marseille, Service d'Imagerie Médicale, Hôpital Nord, Aix Marseille University, 13015, Marseille, France. 7. Assistance Publique Hôpitaux de Marseille, Service des Explorations Fonctionnelles Respiratoires, Aix Marseille University, 13015, Marseille, France. 8. Center for Cardiovascular and Nutrition Research (C2VN), INSERM, INRA, Aix Marseille Université, 13005, Marseille, France. 9. Intensive Care Unit, Department of Anesthesiology, Emergency and Critical Care Medicine, University Hospital Nîmes, 30000, Nîmes, France. 10. Surgical Intensive Care Unit, Shaare Zedek Medical Center, Faculty of Medicine, Hebrew University, Jerusalem, Israel.
Abstract
BACKGROUND: Rapid response teams are intended to improve early diagnosis and intervention in ward patients who develop acute respiratory or circulatory failure. A management protocol including the use of a handheld ultrasound device for immediate point-of-care ultrasound (POCUS) examination at the bedside may improve team performance. The main objective of the study was to assess the impact of implementing such a POCUS-guided management on the proportion of adequate immediate diagnoses in two groups. Secondary endpoints included time to treatment and patient outcomes. METHODS: A prospective, observational, controlled study was conducted in a single university hospital. Two teams alternated every other day for managing in-hospital ward patients developing acute respiratory and/or circulatory failures. Only one of the team used an ultrasound device (POCUS group). RESULTS: We included 165 patients (POCUS group 83, control group 82). Proportion of adequate immediate diagnoses was 94% in the POCUS group and 80% in the control group (p = 0.009). Time to first treatment/intervention was shorter in the POCUS group (15 [10-25] min vs. 34 [15-40] min, p < 0.001). In-hospital mortality rates were 17% in the POCUS group and 35% in the control group (p = 0.007), but this difference was not confirmed in the propensity score sample (29% vs. 34%, p = 0.53). CONCLUSION: Our study suggests that protocolized use of a handheld POCUS device at the bedside in the ward may improve the proportion of adequate diagnosis, the time to initial treatment and perhaps also survival of ward patients developing acute respiratory or circulatory failure. Clinical Trial Registration NCT02967809. Registered 18 November 2016, https://clinicaltrials.gov/ct2/show/NCT02967809 .
RCT Entities:
BACKGROUND: Rapid response teams are intended to improve early diagnosis and intervention in ward patients who develop acute respiratory or circulatory failure. A management protocol including the use of a handheld ultrasound device for immediate point-of-care ultrasound (POCUS) examination at the bedside may improve team performance. The main objective of the study was to assess the impact of implementing such a POCUS-guided management on the proportion of adequate immediate diagnoses in two groups. Secondary endpoints included time to treatment and patient outcomes. METHODS: A prospective, observational, controlled study was conducted in a single university hospital. Two teams alternated every other day for managing in-hospital ward patients developing acute respiratory and/or circulatory failures. Only one of the team used an ultrasound device (POCUS group). RESULTS: We included 165 patients (POCUS group 83, control group 82). Proportion of adequate immediate diagnoses was 94% in the POCUS group and 80% in the control group (p = 0.009). Time to first treatment/intervention was shorter in the POCUS group (15 [10-25] min vs. 34 [15-40] min, p < 0.001). In-hospital mortality rates were 17% in the POCUS group and 35% in the control group (p = 0.007), but this difference was not confirmed in the propensity score sample (29% vs. 34%, p = 0.53). CONCLUSION: Our study suggests that protocolized use of a handheld POCUS device at the bedside in the ward may improve the proportion of adequate diagnosis, the time to initial treatment and perhaps also survival of ward patients developing acute respiratory or circulatory failure. Clinical Trial Registration NCT02967809. Registered 18 November 2016, https://clinicaltrials.gov/ct2/show/NCT02967809 .
Entities:
Keywords:
Handheld ultrasound device; In-hospital emergencies; POCUS; Rapid response team
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